因卡磷酸二钠
因卡磷酸二钠名称
[ CAS 号 ]:
138330-18-4
[ 中文名 ]:
因卡磷酸二钠
[ 英文名 ]:
incadronate
[中文别名 ]:
[英文别名 ]:
- cimadronate
- Incadronate disodiuM
- DisodiuM CycloheptylaMinoMethylene diphosphate
- ym175
- Disodium cycloheptylaminomethylene bisphosphonate
- incadronatesodium
- disodiumcycloheptylaminomethylenediphosphonate
因卡磷酸二钠物理化学性质
[ 沸点 ]:
551.5ºC at 760mmHg
[ 分子式 ]:
C8H17NNa2O6P2
[ 分子量 ]:
331.15100
[ 闪点 ]:
287.4ºC
[ 精确质量 ]:
331.03300
[ PSA ]:
152.37000
[ LogP ]:
2.20510
[ 蒸汽压 ]:
1.28E-13mmHg at 25°C
因卡磷酸二钠毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- SZ7425000
- CHEMICAL NAME :
- Phosphonic acid, ((cycloheptylamino)methylene)bis-, disodium salt
- CAS REGISTRY NUMBER :
- 138330-18-4
- LAST UPDATED :
- 199801
- DATA ITEMS CITED :
- 6
- MOLECULAR FORMULA :
- C8-H17-N-O6-P2.2Na.H2-O
- MOLECULAR WEIGHT :
- 367.22
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 21 mg/kg
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - lacrimation Behavioral - somnolence (general depressed activity) Skin and Appendages - hair
- REFERENCE :
- JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976- Volume(issue)/page/year: 20(Suppl 1),15,1995
- TYPE OF TEST :
- LD - Lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- >10 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Gastrointestinal - nausea or vomiting Nutritional and Gross Metabolic - body temperature decrease
- REFERENCE :
- JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976- Volume(issue)/page/year: 20(Suppl 1),27,1995 ** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 18600 ug/kg/30D-I
- TOXIC EFFECTS :
- Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Skin and Appendages - dermatitis, other (after systemic exposure) Nutritional and Gross Metabolic - changes in calcium
- REFERENCE :
- JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976- Volume(issue)/page/year: 20(Suppl 1),15,1995
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 37500 ug/kg/26W-I
- TOXIC EFFECTS :
- Kidney, Ureter, Bladder - urine volume decreased Kidney, Ureter, Bladder - other changes in urine composition Nutritional and Gross Metabolic - weight loss or decreased weight gain
- REFERENCE :
- JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976- Volume(issue)/page/year: 20(Suppl 1),27,1995
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 30 mg/kg/30D-I
- TOXIC EFFECTS :
- Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Kidney, Ureter, Bladder - other changes in urine composition Blood - changes in bone marrow (not otherwise specified)
- REFERENCE :
- JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976- Volume(issue)/page/year: 20(Suppl 1),27,1995 ** REPRODUCTIVE DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- DOSE :
- 16 mg/kg
- SEX/DURATION :
- female 17-22 day(s) after conception lactating female 21 day(s) post-birth
- TOXIC EFFECTS :
- Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)
- REFERENCE :
- JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976- Volume(issue)/page/year: 20(Suppl 1),1,1995
相关化工产品/化学物质：
相关药品：
推荐生产厂家/供应商：
公司名：上海化源生化科技有限公司
区域：上海市普陀区
价格：
联系人：化源
产品详情：因卡磷酸二钠
公司名：上海阿拉丁生化科技股份有限公司
区域：上海市浦东新区
价格：
￥450.0/25mg
￥2430.0/100mg
￥需询单/1g
￥需询单/1g
联系人：阿拉丁
产品详情：因卡磷酸二钠
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相关化合物
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