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腺苷钴胺

腺苷钴胺用途

Adenosylcobalamin (Coenzyme B12;Cobamamide;AdoCbl) 是 Vitamin B12 的一种活性形式,Vitamin B12 是是甲基丙二酰 CoA 突变酶的辅助因子。

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腺苷钴胺名称

[ CAS 号 ]:
13870-90-1

[ 中文名 ]:
腺苷钴胺

[ 英文名 ]:
coenzyme B12

[中文别名 ]:

[英文别名 ]:

5'-Deoxyadenosylcobalamin
DBC
Coenzyme B12
Dibenzcozamide
Coenzyme B12
DBC coenzyme
Adenosyl cobalamine
Indusil T
α-(5,6-Dimethylbenzimidazolyl)cobamide coenzyme
Vitamin B12 coenzyme

腺苷钴胺生物活性

[ 描述 ]:

Adenosylcobalamin (Coenzyme B12;Cobamamide;AdoCbl) 是 Vitamin B12 的一种活性形式,Vitamin B12 是是甲基丙二酰 CoA 突变酶的辅助因子。

[ 相关类别 ]:

研究领域 >> 代谢疾病

[体外研究]

腺苷钴胺是一组酶的辅因子,这些酶催化不寻常的重排或消除反应[1]。

[参考文献]

[1]. Kumudha A, et al. Characterization of vitamin B12 in Dunaliella salina. J Food Sci Technol. 2016 Jan;53(1):888-94.

[2]. Marsh EN, et al. Adenosylcobalamin enzymes: Theory and experiment begin to converge. Biochim Biophys Acta. 2012 Nov;1824(11):1154-64.

腺苷钴胺物理化学性质

[ 分子式 ]:
C₇₂H₉₉CoN₁₈O₁₇P

[ 分子量 ]:
1579.582

[ 精确质量 ]:
1578.658325

[ PSA ]:
583.18000

[ LogP ]:
6.19200

[ 储存条件 ]:
2-8°C

腺苷钴胺MSDS

详细MSDS(安全技术说明书)

腺苷钴胺毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GG3800000

CHEMICAL NAME :: Cobinamide, O-(5'-deoxyadenosine-5') deriv., hydroxide, dihydrogen phosphate (ester), inner salt, 3'-ester with 5,6-dimethyl-1-alpha-D-ribofuranosylbenzimidazole

CAS REGISTRY NUMBER :: 13870-90-1

LAST UPDATED :: 199612

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C72-H100-Co-N18-O17-P

MOLECULAR WEIGHT :: 1579.80

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,405,1990

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,405,1990

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,405,1990

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,405,1990

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,405,1990

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,405,1990

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腺苷钴胺安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S22-S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
GG3800000

[ 海关编码 ]:
2936260000

腺苷钴胺海关

[ 海关编码 ]: 2936260000

腺苷钴胺文献

Thermophilic Coenzyme B12-Dependent Acyl Coenzyme A (CoA) Mutase from Kyrpidia tusciae DSM 2912 Preferentially Catalyzes Isomerization of (R)-3-Hydroxybutyryl-CoA and 2-Hydroxyisobutyryl-CoA.

Appl. Environ. Microbiol. 81 , 4564-72, (2015)

The recent discovery of a coenzyme B12-dependent acyl-coenzyme A (acyl-CoA) mutase isomerizing 3-hydroxybutyryl- and 2-hydroxyisobutyryl-CoA in the mesophilic bacterium Aquincola tertiaricarbonis L108...

Assessing the stability of membrane proteins to detect ligand binding using differential static light scattering.

J. Biomol. Screen. 15 , 314-20, (2010)

Protein stabilization upon ligand binding has frequently been used to identify ligands for soluble proteins. Methods such as differential scanning fluorimetry (DSF) and differential static light scatt...

Chemical screening methods to identify ligands that promote protein stability, protein crystallization, and structure determination.

Proc. Natl. Acad. Sci. U. S. A. 103 , 15835-40, (2006)

The 3D structures of human therapeutic targets are enabling for drug discovery. However, their purification and crystallization remain rate determining. In individual cases, ligands have been used to ...

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