1-(2-Chloroethyl)-3-(2,6-dioxo-3-piperid yl)-1-nitrosourea

名称

[ CAS 号 ]:
13909-02-9

[ 英文名 ]:
1-(2-Chloroethyl)-3-(2,6-dioxo-3-piperid yl)-1-nitrosourea

[英文别名 ]:

pcnu

物理化学性质

[ 密度 ]:
1.68g/cm3

[ 分子式 ]:
C₈H₁₁ClN₄O₄

[ 分子量 ]:
262.65000

[ 精确质量 ]:
262.04700

[ PSA ]:
107.94000

[ LogP ]:
0.44310

[ 折射率 ]:
1.664

[ 储存条件 ]:
库房低温通风干燥,与食品原料分开存放

毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: YS4915000

CHEMICAL NAME :: Urea, 1-(2-chloroethyl)-3-(2,6-dioxo-3-piperidyl)-1-nitroso -

CAS REGISTRY NUMBER :: 13909-02-9

LAST UPDATED :: 199801

DATA ITEMS CITED :: 12

MOLECULAR FORMULA :: C8-H11-Cl-N4-O4

MOLECULAR WEIGHT :: 262.68

WISWESSER LINE NOTATION :: T6VMVTJ DMVNNO&2G

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 35700 ug/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - effect, not otherwise specified Behavioral - somnolence (general depressed activity) Behavioral - food intake (animal)

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 15210 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 22 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 3 mg/kg

TOXIC EFFECTS :: Behavioral - food intake (animal) Gastrointestinal - changes in structure or function of salivary glands Gastrointestinal - nausea or vomiting

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Primate - monkey

DOSE/DURATION :: 10 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 15 mg/kg/10D-I

TOXIC EFFECTS :: Gastrointestinal - hypermotility, diarrhea Liver - changes in liver weight Nutritional and Gross Metabolic - body temperature increase

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 15 mg/kg/5D-I

TOXIC EFFECTS :: Gastrointestinal - hypermotility, diarrhea Liver - changes in liver weight Nutritional and Gross Metabolic - body temperature increase

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Primate - monkey

DOSE/DURATION :: 50 mg/kg/5D-I

TOXIC EFFECTS :: Gastrointestinal - ulceration or bleeding from stomach Liver - changes in liver weight Related to Chronic Data - death

MUTATION DATA

TYPE OF TEST :: Mutation test systems - not otherwise specified

TEST SYSTEM :: Rodent - mouse Leukocyte

DOSE/DURATION :: 16 mg/kg

REFERENCE :: INSSDM INSERM Symposium. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) No.1- 1975- Volume(issue)/page/year: 19,85,1981

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安全信息

[ 海关编码 ]:
2924199090

海关

[ 海关编码 ]: 2924199090

[ 中文概述 ]:
2924199090. 其他无环酰胺（包括无环氨基甲酸酯)(包括其衍生物及盐）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 包装

[ Summary ]:
2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%