1-(2-chloroethyl)-1-nitroso-3-(2-norb-ornyl)urea

名称

[ CAS 号 ]:
13909-13-2

[ 英文名 ]:
1-(2-chloroethyl)-1-nitroso-3-(2-norb-ornyl)urea

物理化学性质

[ 密度 ]:
1.52g/cm3

[ 分子式 ]:
C₁₀H₁₆ClN₃O₂

[ 分子量 ]:
245.70600

[ 精确质量 ]:
245.09300

[ PSA ]:
61.77000

[ LogP ]:
2.49770

[ 折射率 ]:
1.668

[ 储存条件 ]:
库房低温通风干燥,与食品原料分开存放

毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: YS5075000

CHEMICAL NAME :: Urea, 1-(2-chloroethyl)-1-nitroso-3-(2-norbornyl)-

CAS REGISTRY NUMBER :: 13909-13-2

LAST UPDATED :: 199612

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C10-H16-Cl-N3-O2

MOLECULAR WEIGHT :: 245.74

WISWESSER LINE NOTATION :: L55 ATJ CMVNNO&2G

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 83 mg/kg

TOXIC EFFECTS :: Liver - jaundice, other or unclassified Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: NCIMR* Progress Report Submitted to the National Cancer Institute by Mason Research Institute. (Worcester, MA) Volume(issue)/page/year: -,372,1968

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 56 mg/kg

TOXIC EFFECTS :: Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: NCIMR* Progress Report Submitted to the National Cancer Institute by Mason Research Institute. (Worcester, MA) Volume(issue)/page/year: -,372,1968

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 54760 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NCISP* National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. (Bethesda, MD 20205) Volume(issue)/page/year: JAN1986 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 18750 ug/kg/15D-I

TOXIC EFFECTS :: Blood - normocytic anemia Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphatases Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases

REFERENCE :: NCIMR* Progress Report Submitted to the National Cancer Institute by Mason Research Institute. (Worcester, MA) Volume(issue)/page/year: -,372,1968

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 15 mg/kg/5W-I

TOXIC EFFECTS :: Liver - change in gall bladder structure or function Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases

REFERENCE :: NCIMR* Progress Report Submitted to the National Cancer Institute by Mason Research Institute. (Worcester, MA) Volume(issue)/page/year: -,372,1968

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Primate - monkey

DOSE/DURATION :: 35 mg/kg/15D-I

TOXIC EFFECTS :: Liver - fatty liver degeneration Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: NCIMR* Progress Report Submitted to the National Cancer Institute by Mason Research Institute. (Worcester, MA) Volume(issue)/page/year: -,372,1968

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安全信息

[ 海关编码 ]:
2924299090

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海关

[ 海关编码 ]: 2924299090

[ 中文概述 ]:
2924299090. 其他环酰胺（包括环氨基甲酸酯）（包括其衍生物以及他们的盐）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 包装

[ Summary ]:
2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%