Restrictocin

Restrictocin是一种生物化学试剂,可作为生物材料或有机化合物用于生命科学相关研究。

[ 描述 ]:

[ 相关类别 ]:

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
577.7±50.0 °C at 760 mmHg

[ 分子式 ]:
C₂₁H₂₉N₃O₂

[ 分子量 ]:
355.474

[ 闪点 ]:
303.2±30.1 °C

[ 精确质量 ]:
355.225983

[ LogP ]:
2.79

[ 蒸汽压 ]:
0.0±1.6 mmHg at 25°C

[ 折射率 ]:
1.582

[ 符号 ]:

GHS07, GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H302-H312-H317-H332-H334

[ 警示性声明 ]:
P261-P280-P342 + P311

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ 危险品运输编码 ]:
NONH for all modes of transport

[ RTECS号 ]:
VH4725000

The ribotoxin restrictocin recognizes its RNA substrate by selective engagement of active site residues.

Biochemistry 50(14) , 3004-13, (2011)

Restrictocin and related fungal endoribonucleases from the α-sarcin family site-specifically cleave the sarcin/ricin loop (SRL) on the ribosome to inhibit translation and ultimately trigger cell death...

Role of individual cysteine residues and disulfide bonds in the structure and function of Aspergillus ribonucleolytic toxin restrictocin.

Biochemistry 38(31) , 10052-8, (1999)

Restrictocin, produced by the fungus Aspergillus restrictus, belongs to the group of ribonucleolytic toxins called ribotoxins. It specifically cleaves a single phosphodiester bond in a conserved stem ...

Mechanism of specific target recognition and RNA hydrolysis by ribonucleolytic toxin restrictocin.

Biochemistry 40(31) , 9115-24, (2001)

Restrictocin, a member of the fungal ribotoxin family, specifically cleaves a single phosphodiester bond in the 28S rRNA and potently inhibits eukaryotic protein synthesis. Residues Tyr47, His49, Glu9...

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