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盐酸黄连素水合物

盐酸黄连素水合物用途

用于治疗肠道感染的植物抗菌素

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盐酸黄连素水合物名称

[ CAS 号 ]:
141433-60-5

[ 中文名 ]:
盐酸小檗碱

[ 英文名 ]:
Berberine (chloride hydrate)

[中文别名 ]:

[英文别名 ]:

Natural Yellow 18 Hydrate
BERBERIN HCL
Berberine chloride
EINECS 211-195-9
Berberin hydrochloride
BBR
UMBELLATINE
Berberine Chloride Hydrate
BERBERINE HCL
MFCD00011939

盐酸黄连素水合物物理化学性质

[ 熔点 ]:
204-206 °C (dec.)

[ 分子式 ]:
C₂₀H₁₈ClNO₄

[ 分子量 ]:
371.814

[ 精确质量 ]:
371.092438

[ PSA ]:
40.80000

[ LogP ]:
0.10030

[ 外观性状 ]:
固体;White to Yellow to Orange powder to crystaline

[ 储存条件 ]:
存放于惰性气体之中;避免湿气 (吸湿)

盐酸黄连素水合物MSDS

详细MSDS(安全技术说明书)

盐酸黄连素水合物安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xn

[ 风险声明 (欧洲) ]:
20/21/22

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
2

[ RTECS号 ]:
DR9866400

[ 海关编码 ]:
3003409000

盐酸黄连素水合物制备

1.取三颗针薄片或粗粉500g，用5倍量0.2%(体积分数)硫酸水溶液浸渍3次,每次36h,浸提时不断搅拌。滤取浸出液,加石灰粉调pH值9～11,再滤除沉淀,滤液中加质量浓度为7%的固体工业食盐,搅拌使其溶解,放置后过滤。滤出的沉淀加少量水洗1～2次,除去多余的盐,吊干后,于80℃干燥,得黄连素粗品。取粗品加适量水溶解(水量约为干品的30倍或湿品的10倍),加热30min,趁热过滤,取滤液,再加浓HCl,调pH值1～2,放置2h后过滤,滤出的沉淀再用少量蒸馏水洗至pH值为5,抽干,于80℃干燥,可得盐酸黄连素精品。

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盐酸黄连素水合物海关

[ 海关编码 ]: 3003409000

盐酸黄连素水合物文献

Berberine blocks the relapse of Clostridium difficile infection in C57BL/6 mice after standard vancomycin treatment.

Antimicrob. Agents Chemother. 59 , 3726-35, (2015)

Vancomycin is a preferred antibiotic for treating Clostridium difficile infection (CDI) and has been associated with a rate of recurrence of CDI of as high as 20% in treated patients. Recent studies h...

Synergistic topical application of salt-processed Phellodendron amurense and Sanguisorba officinalis Linne alleviates atopic dermatitis symptoms by reducing levels of immunoglobulin E and pro-inflammatory cytokines in NC/Nga mice.

Mol. Med. Report. 12 , 7657-64, (2015)

Atopic dermatitis is a chronic inflammatory skin disease, and salt-processed Phellodendron amurense (CPE) and Sanguisorba officinalis Linne (SOE) are widely used as anti-inflammatory agents in Asia. T...

Berberine induces senescence of human glioblastoma cells by downregulating the EGFR-MEK-ERK signaling pathway.

Mol. Cancer Ther. 14(2) , 355-63, (2015)

Glioblastoma multiforme (GBM) is the most common primary malignant brain tumor and has a poor prognosis. We, here, report a potent antitumor effect of berberine, an isoquinoline alkaloid, on GBM. Berb...

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