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前列腺素 A 1

前列腺素 A 1用途

用于生化研究

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前列腺素 A 1名称

[ CAS 号 ]:
14152-28-4

[ 中文名 ]:
前列腺素 A1

[ 英文名 ]:
PROSTAGLANDIN A1

[英文别名 ]:

Prostaglandin A1
MFCD00077858

前列腺素 A 1物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
510.7±50.0 °C at 760 mmHg

[ 熔点 ]:
41 - 43ºC

[ 分子式 ]:
C₂₀H₃₂O₄

[ 分子量 ]:
336.466

[ 闪点 ]:
276.7±26.6 °C

[ 精确质量 ]:
336.230072

[ PSA ]:
74.60000

[ LogP ]:
3.61

[ 外观性状 ]:
白色至黄色结晶固体

[ 蒸汽压 ]:
0.0±3.0 mmHg at 25°C

[ 折射率 ]:
1.541

[ 储存条件 ]:
−20°C

[ 水溶解性 ]:
acetone: 10 mg/mL, clear

前列腺素 A 1MSDS

详细MSDS(安全技术说明书)

前列腺素 A 1毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GY5977900

CHEMICAL NAME :: 3-Cyclopentene-1-heptanoic acid, 2-(3-hydroxy-1-octenyl)-5-oxo-

CAS REGISTRY NUMBER :: 14152-28-4

LAST UPDATED :: 198910

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C20-H32-O4

MOLECULAR WEIGHT :: 336.52

WISWESSER LINE NOTATION :: T5V BUTJ D2YQ5 E6VQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 12 mg/kg

SEX/DURATION :: male 10 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - other effects on male

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravaginal

DOSE :: 169 ug/kg

SEX/DURATION :: female 17 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravaginal

DOSE :: 169 ug/kg

SEX/DURATION :: female 17 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) Reproductive - Specific Developmental Abnormalities - urogenital system Reproductive - Specific Developmental Abnormalities - other developmental abnormalities

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 10 mg/kg

SEX/DURATION :: female 16 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetal death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 40 mg/kg

SEX/DURATION :: female 16 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - abortion

MUTATION DATA

TYPE OF TEST :: Mutation test systems - not otherwise specified

TEST SYSTEM :: Human Cells - not otherwise specified

DOSE/DURATION :: 2500 ug/L

REFERENCE :: CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 43,513,1983

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前列腺素 A 1安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xn

[ 安全声明 (欧洲) ]:
S22-S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
GY5977900

前列腺素 A 1文献

The cyclopentenone prostaglandin 15d-PGJ2 inhibits the NLRP1 and NLRP3 inflammasomes.

J. Immunol. 194(6) , 2776-85, (2015)

Inflammasomes are cytosolic protein complexes that respond to diverse danger signals by activating caspase-1. The sensor components of the inflammasome, often proteins of the nucleotide-binding oligom...

Protective effects of n-6 fatty acids-enriched diet on intestinal ischaemia/reperfusion injury involve lipoxin A4 and its receptor.

Br. J. Pharmacol. 172(3) , 910-23, (2015)

Long-term intake of dietary fatty acids is known to predispose to chronic inflammation, but their effects on acute intestinal ischaemia/reperfusion (I/R) injury is unknown. The aim of this study was t...

Vimentin filament organization and stress sensing depend on its single cysteine residue and zinc binding.

Nat. Commun. 6 , 7287, (2015)

The vimentin filament network plays a key role in cell architecture and signalling, as well as in epithelial-mesenchymal transition. Vimentin C328 is targeted by various oxidative modifications, but i...

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