硫酸可待因

硫酸可待因名称

[ 英文名 ]:
(4R,4aR,7S,7aR,12bS)-9-methoxy-3-methyl-2,4,4a,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-7-ol,sulfuric acid

[英文别名 ]:

UNII-AVW5HY4N2E
Codeine sulfate anhydrous
EINECS 215-818-5
codeine sulfate
Codeine sulphate

硫酸可待因物理化学性质

[ 沸点 ]:
462ºC at 760mmHg

[ 分子式 ]:
C₁₈H₂₃NO₇S

[ 分子量 ]:
397.44300

[ 闪点 ]:
233.2ºC

[ 精确质量 ]:
397.12000

[ PSA ]:
124.91000

[ LogP ]:
1.86700

[ 蒸汽压 ]:
2.47E-09mmHg at 25°C

硫酸可待因毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QD1400000

CAS REGISTRY NUMBER :: 1420-53-7

LAST UPDATED :: 199504

DATA ITEMS CITED :: 12

MOLECULAR FORMULA :: C36-H42-N2-O6.O4-S

MOLECULAR WEIGHT :: 694.86

WISWESSER LINE NOTATION :: T B6566 B6/CO 4ABBC R BX HO PN DU GHT&&TTJ FQ JO1 P & 2WSQQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 430 mg/kg

TOXIC EFFECTS :: Behavioral - analgesia

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 107 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - excitement Behavioral - rigidity (including catalepsy)

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 332 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 55 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 395 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 143 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia Lungs, Thorax, or Respiration - other changes

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 183 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 68 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 100 mg/kg

SEX/DURATION :: female 9 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - musculoskeletal system Reproductive - Effects on Newborn - sex ratio

MUTATION DATA

TEST SYSTEM :: Fish - not otherwise specified

DOSE/DURATION :: 100 mg/L

REFERENCE :: BEXBBO Biochemistry and Experimental Biology. (Padua, Italy) V.10-16, 1971/72-80. Suspended. Volume(issue)/page/year: 16,425,1980 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 81365 No. of Facilities: 33 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 429 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 81365 No. of Facilities: 86 (estimated) No. of Industries: 1 No. of Occupations: 4 No. of Employees: 5578 (estimated) No. of Female Employees: 4863 (estimated)

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硫酸可待因安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302

[ 警示性声明 ]:
P301 + P312 + P330

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ 危害码 (欧洲) ]:
Xn: Harmful;

[ 风险声明 (欧洲) ]:
22

[ 危险品运输编码 ]:
NONH for all modes of transport

[ RTECS号 ]:
QD1400000

硫酸可待因文献

Pharmacokinetics of opioids in liver disease.

Clin. Pharmacokinet. 37 , 17-40, (1999)

The liver is the major site of biotransformation for most opioids. Thus, the disposition of these drugs may be affected in patients with liver insufficiency. The major metabolic pathway for most opioi...

Respiratory effects of opioid full and partial agonists in rhesus monkeys.

J. Pharmacol. Exp. Ther. 277 , 462-472, (1996)

Respiratory and behavioral effects of the mu selective opioids levorphanol (0.01-3.0 mg/kg), methadone (0.03-5.6 mg/kg) and codeine (0.3-30.0 mg/kg) and the mixed-action opioids buprenorphine (0.003-1...

Biochemical effects of Catha edulis, cathine and cathinone on adrenocortical functions.

J. Ethnopharmacol. 39(3) , 213, (1993)

Catha edulis is a plant that grows in certain areas of East Africa and the Arab Peninsula. The stimulating properties of fresh material were described more than seven centuries ago and today the habit...

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