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盐酸士的宁

盐酸士的宁用途

Strychnine Hydrochloride is a neurotoxin that acts as an antagonist of glycine and acetylcholine receptors.

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盐酸士的宁名称

[ CAS 号 ]:
1421-86-9

[ 中文名 ]:
盐酸马钱子碱

[ 英文名 ]:
Strychnidin-10-one hydrochloride (1:1)

[英文别名 ]:

strychnine*HCl
Strychnin,Hydrochlorid
MFCD00058174
strychnine,monohydrochloride
Strychnidin-10-onehydrochloride
EINECS 215-826-9
Strychnidin-10-one, hydrochloride (1:1)
strychnine,hydrochloride
Strychnidin-10-one hydrochloride (1:1)
Strychnidin-10-one, monohydrochloride (9CI)

盐酸士的宁物理化学性质

[ 沸点 ]:
559.9ºC at 760mmHg

[ 熔点 ]:
295 °C

[ 分子式 ]:
C₂₁H₂₃ClN₂O₂

[ 分子量 ]:
370.872

[ 闪点 ]:
292.4ºC

[ 精确质量 ]:
370.144806

[ PSA ]:
32.78000

[ LogP ]:
2.89740

[ 外观性状 ]:
白色至浅米色固体

[ 蒸汽压 ]:
1.44E-12mmHg at 25°C

[ 储存条件 ]:
Store at RT

盐酸士的宁MSDS

详细MSDS(安全技术说明书)

盐酸士的宁毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: WL2430000

CHEMICAL NAME :: Strychnine, monohydrochloride

CAS REGISTRY NUMBER :: 1421-86-9

LAST UPDATED :: 199106

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C21-H22-N2-O2.Cl-H

MOLECULAR WEIGHT :: 370.91

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2730 ug/kg

TOXIC EFFECTS :: Behavioral - rigidity (including catalepsy)

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 650 ug/kg

TOXIC EFFECTS :: Behavioral - general anesthetic

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 460 ug/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - dyspnea

MUTATION DATA

TYPE OF TEST :: Gene conversion and mitotic recombination

TEST SYSTEM :: Bacteria - Salmonella typhimurium

DOSE/DURATION :: 3 mmol/L

REFERENCE :: EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 10,27,1987

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盐酸士的宁安全信息

[ 符号 ]:

GHS06, GHS09

[ 信号词 ]:
Danger

[ 危害声明 ]:
H300-H330-H410

[ 警示性声明 ]:
P260-P264-P273-P284-P301 + P310-P310

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
T+: Very toxic;N: Dangerous for the environment;

[ 风险声明 (欧洲) ]:
R26/27/28

[ 安全声明 (欧洲) ]:
S22-S36/37/39-S45-S61-S60

[ 危险品运输编码 ]:
UN 1692 6.1/PG 1

[ WGK德国 ]:
3

[ RTECS号 ]:
WL2430000

[ 包装等级 ]:
I

[ 危险类别 ]:
6.1(a)

盐酸士的宁文献

Parallel ON and OFF cone bipolar inputs establish spatially coextensive receptive field structure of blue-yellow ganglion cells in primate retina.

J. Mol. Endocrinol. 29 , 8372-87, (2009)

In the primate retina the small bistratified, "blue-yellow" color-opponent ganglion cell receives parallel ON-depolarizing and OFF-hyperpolarizing inputs from short (S)-wavelength sensitive and combin...

Phosphocholine-Modified Macromolecules and Canonical Nicotinic Agonists Inhibit ATP-Induced IL-1β Release.

J. Immunol. 195 , 2325-34, (2015)

IL-1β is a potent proinflammatory cytokine of the innate immune system that is involved in host defense against infection. However, increased production of IL-1β plays a pathogenic role in various inf...

Inhibitory Interneurons That Express GFP in the PrP-GFP Mouse Spinal Cord Are Morphologically Heterogeneous, Innervated by Several Classes of Primary Afferent and Include Lamina I Projection Neurons among Their Postsynaptic Targets.

J. Neurosci. 35 , 7626-42, (2015)

The superficial dorsal horn of the spinal cord contains numerous inhibitory interneurons, which regulate the transmission of information perceived as touch, pain, or itch. Despite the importance of th...

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