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3-甲基-2-苯并噻唑啉酮腙盐酸盐

3-甲基-2-苯并噻唑啉酮腙盐酸盐用途

3-甲基-2-苯并噻唑酮腙可作染料的中间体。其盐酸盐MBTH是比色测定脂肪族醛和芒香族胺类的试剂。

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3-甲基-2-苯并噻唑啉酮腙盐酸盐名称

[ CAS 号 ]:
14448-67-0

[ 中文名 ]:
3-甲基-2-苯并噻唑啉酮腙盐酸盐

[ 英文名 ]:
2-HYDRAZONO-3-METHYL-2,3-DIHYDROBENZO[D]THIAZOLE HYDROCHLORIDE

[中文别名 ]:

3-甲基地-苯并噻唑酮腙盐酸盐

[英文别名 ]:

3-Methylbenzothiazol-2(3H)-onehydrazoneHCl
3-Methyl-2-benzothiazolinone hydrazone HCI
3-METHYL-2-BENZOTHIAZOLINONE HYDRAZONE HCL
3-METHYLBENZOTHIAZOL-2-ONE HYDRAZONE HYDROCHLORIDE
MBTH HCL
3-Methyl-2-BenzothiazolinoneHydrazoneHcl(Mbth)

3-甲基-2-苯并噻唑啉酮腙盐酸盐物理化学性质

[ 沸点 ]:
369.6ºC at 760 mmHg

[ 熔点 ]:
276-278℃（分解）

[ 分子式 ]:
C₈H₁₀ClN₃S

[ 分子量 ]:
215.70300

[ 闪点 ]:
177.4ºC

[ 精确质量 ]:
215.02800

[ PSA ]:
71.55000

[ LogP ]:
2.51650

[ 外观性状 ]:
白色粉末

[ 蒸汽压 ]:
8.02E-06mmHg at 25°C

[ 储存条件 ]:
室温，干燥，密封

3-甲基-2-苯并噻唑啉酮腙盐酸盐毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DL7160200

CHEMICAL NAME :: 2(3H)-Benzothiazolone, 3-methyl-, hydrazone, hydrochloride

CAS REGISTRY NUMBER :: 14448-67-0

LAST UPDATED :: 199806

DATA ITEMS CITED :: 8

MOLECULAR FORMULA :: C8-H9-N3-S.Cl-H

MOLECULAR WEIGHT :: 215.72

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 149 mg/kg

TOXIC EFFECTS :: Behavioral - changes in motor activity (specific assay) Lungs, Thorax, or Respiration - other changes Gastrointestinal - other changes

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >16 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 177 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - changes in motor activity (specific assay) Lungs, Thorax, or Respiration - other changes

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 12300 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation) Behavioral - tremor Behavioral - convulsions or effect on seizure threshold

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Salmonella typhimurium

DOSE/DURATION :: 1 mg/plate

REFERENCE :: TIHEEC Toxicology and Industrial Health. (Princeton Scientific Pub. Co., POB 2155, Princeton, NJ 08540) V.1- 1985- Volume(issue)/page/year: 4,23,1988 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X6634 No. of Facilities: 25 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 1358 (estimated) No. of Female Employees: 956 (estimated)

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3-甲基-2-苯并噻唑啉酮腙盐酸盐制备

由2-氨基苯并噻唑用硫酸二甲酯甲基化后再与水合肼缩合，得到3-甲基-2-苯并噻唑酮腙[1128-67-2]，最后用盐酸成盐即得成该品。在搪玻璃反应锅中加入无水氯仿和2-氨基苯并噻唑，加热到60 -61 ℃ ，搅拌15min，使2-氨基苯并噻唑溶解形成透明的溶液。冷却到 40℃ ，加入硫酸二甲酯，加热回收氯仿60 -61 ℃ ，搅拌反应1h。加水，加热回收氯仿至 98℃ 。氯仿回收结束后，加水合肼，升温至85 -87 ℃ ，然后温度自行上升至 99 ℃ ，于98 -99 ℃ 保持反应6h，反应过程中自始至终保持亮黄试纸显红。缩合反应完毕，加水，冷却至 30℃ ，过滤，滤饼用水洗至对亮黄试纸不显色，得3-甲基-2-苯并噻唑酮腙。收率约60%。用盐酸成盐即得MBTH。

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3-甲基-2-苯并噻唑啉酮腙盐酸盐

3-甲基-2-苯并噻唑啉酮腙盐酸盐用途

3-甲基-2-苯并噻唑啉酮腙盐酸盐名称

3-甲基-2-苯并噻唑啉酮腙盐酸盐物理化学性质

3-甲基-2-苯并噻唑啉酮腙盐酸盐毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

3-甲基-2-苯并噻唑啉酮腙盐酸盐制备

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