6-氯-9-[3-n-(2-氯乙基)乙基氨基]丙基氨基-2-甲氧基吖啶双盐酸盐

用途

用于诱变物和致癌物的检定和分类。

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名称

[ CAS 号 ]:
146-59-8

[ 中文名 ]:
6-氯-9-[3-n-(2-氯乙基)乙基氨基]丙基氨基-2-甲氧基吖啶双盐酸盐

[ 英文名 ]:
6-CHLORO-9-[3-N-(2-CHLOROETHYL)ETHYLAMINO]PROPYLAMINO-2-METHOXYACRIDINE DIHYDROCHLORIDE

[英文别名 ]:

MFCD00012658
acridine mutagen ICR 170 dihydrochloride
ICR 170 ACRIDINE MUTAGEN*DIHYDROCHLORIDE
icr170
EINECS 205-675-7
ACRIDINEICR170
acridinemustard

物理化学性质

[ 沸点 ]:
546.9ºC at 760mmHg

[ 熔点 ]:
231-232ºC

[ 分子式 ]:
C₂₁H₂₇Cl₄N₃O

[ 分子量 ]:
479.27100

[ 闪点 ]:
284.5ºC

[ 精确质量 ]:
477.09100

[ PSA ]:
37.39000

[ LogP ]:
7.08970

[ 蒸汽压 ]:
5.17E-12mmHg at 25°C

[ 储存条件 ]:
库房通风低温干燥

毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AR7680000

CHEMICAL NAME :: Acridine, 6-chloro-9-(3-(N-(2-chloroethyl)-N-ethylamino)propyla mino)-2-methoxy-, dihydrochloride

CAS REGISTRY NUMBER :: 146-59-8

LAST UPDATED :: 199710

DATA ITEMS CITED :: 47

MOLECULAR FORMULA :: C21-H25-Cl2-N3-O.2Cl-H

MOLECULAR WEIGHT :: 479.31

WISWESSER LINE NOTATION :: T C666 BNJ EG IM3N2&2G LO1 &GH &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD20 - Lethal Dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2 mg/kg

TOXIC EFFECTS :: Tumorigenic - active as anti-cancer agent

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 5 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 4800 ug/kg/28D-I

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Lungs, Thorax, or Respiration - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 4 mg/kg

SEX/DURATION :: female 1 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth)

TYPE OF TEST :: Specific locus test

TYPE OF TEST :: Sex chromosome loss and nondisjunction

TYPE OF TEST :: Sex chromosome loss and nondisjunction

MUTATION DATA

TYPE OF TEST :: Unscheduled DNA synthesis

TEST SYSTEM :: Mammal - species unspecified Lymphocyte

DOSE/DURATION :: 1 umol/L

REFERENCE :: CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1969- Volume(issue)/page/year: 8,113,1974

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安全信息

[ 危害码 (欧洲) ]:
T: Toxic;

[ 风险声明 (欧洲) ]:
68-40-23/24/25

[ 安全声明 (欧洲) ]:
S22;S45;S36/S37/S39

[ 危险品运输编码 ]:
UN 2811

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1(b)