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反式-二氨二氯合铂(II)

反式-二氨二氯合铂(II)用途

抗癌药物。

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反式-二氨二氯合铂(II)名称

[ CAS 号 ]:
14913-33-8

[ 中文名 ]:
反式二氨二氯合铂

[ 英文名 ]:
trans-Dichlorodiamineplatinum(II)

[中文别名 ]:

[英文别名 ]:

trans--diamminedichloroplatinum(II)
EINECS 238-980-9
trans-diamminodichloroplatinum(II)
trans-diaminedichloroplatinum(II)
UNII:Q20Q21Q62J
Dichloroplatinum diammoniate
trans-Platinum diammine dichloride
MFCD00011623
CIS-PLATIN
transplatin

反式-二氨二氯合铂(II)物理化学性质

[ 密度 ]:
3.746 g/cm3

[ 熔点 ]:
340ºC (dec.)

[ 分子式 ]:
H₆Cl₂N₂Pt

[ 分子量 ]:
300.051

[ 精确质量 ]:
298.955597

[ PSA ]:
6.48000

[ LogP ]:
2.02430

[ 外观性状 ]:
黄色粉末或晶体

[ 折射率 ]:
1.706

[ 储存条件 ]:
室温

[ 水溶解性 ]:
Soluble in dimethylsulfoxide and dimethylformamide. Slightly soluble in water.

反式-二氨二氯合铂(II)MSDS

详细MSDS(安全技术说明书)

反式-二氨二氯合铂(II)毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TP2455000

CHEMICAL NAME :: Platinum (II), diamminedichloro-, trans-

CAS REGISTRY NUMBER :: 14913-33-8

LAST UPDATED :: 199709

DATA ITEMS CITED :: 28

MOLECULAR FORMULA :: Cl2-H6-N2-Pt

MOLECULAR WEIGHT :: 300.07

WISWESSER LINE NOTATION :: .PT..ZH2.G2 -T

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 27 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 32408 ug/kg/10W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors

MUTATION DATA

TYPE OF TEST :: DNA adduct

TEST SYSTEM :: Mammal - species unspecified Lymphocyte

DOSE/DURATION :: 50 umol/L

REFERENCE :: CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1969- Volume(issue)/page/year: 10,27,1975

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反式-二氨二氯合铂(II)安全信息

[ 符号 ]:

GHS05, GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H317-H318-H334

[ 警示性声明 ]:
P261-P280-P284-P304 + P340-P305 + P351 + P338 + P310

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ 危害码 (欧洲) ]:
T:Toxic;

[ 风险声明 (欧洲) ]:
R23/24/25;R40;R42/43;R68

[ 安全声明 (欧洲) ]:
S24-S36/37

[ 危险品运输编码 ]:
UN 3288

[ WGK德国 ]:
3

[ RTECS号 ]:
TP2455000

[ 包装等级 ]:
II

[ 危险类别 ]:
6.1(a)

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