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N-(3-三乙基铵丙基)-4-(4-(二丁基氨基)苯乙烯基)吡啶二溴盐

用途

FM1-43是一种用于研究内吞和外吐的苯乙烯基染料,其作用是作为毛细胞机械传递通道的渗透阻滞剂。FM1-43还可降低氨基糖苷类抗生素硫酸新霉素的耳毒性作用[1]。

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名称

[ CAS 号 ]:
149838-22-2

[ 中文名 ]:
N-(3-三乙基铵丙基)-4-(4-(二丁基氨基)苯乙烯基)吡啶二溴盐

[ 英文名 ]:
FM1-43

[英文别名 ]:

Neurodye GH1-43
SynaptoGreen™ C4

生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 神经疾病

[参考文献]

[1]. J E Gale, et al. FM1-43 dye behaves as a permeant blocker of the hair-cell mechanotransducer channel. J Neurosci. 2001 Sep 15;21(18):7013-25.

物理化学性质

[ 分子式 ]:
C₃₀H₄₉Br₂N₃

[ 分子量 ]:
611.53800

[ 精确质量 ]:
609.22900

[ PSA ]:
7.12000

[ LogP ]:
0.82570

[ 外观性状 ]:
暗红色固体

[ 储存条件 ]:
室温，避光，干燥

MSDS

详细MSDS(安全技术说明书)

安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

文献

Regulation of density of functional presynaptic terminals by local energy supply.

Mol. Brain 8 , 42, (2015)

The density of functional synapses is an important parameter in determining the efficacy of synaptic transmission. However, how functional presynaptic terminal density is regulated under natural physi...

A genomic region encompassing a newly identified exon provides enhancing activity sufficient for normal myo7aa expression in zebrafish sensory hair cells.

Dev. Neurobiol. 75 , 961-83, (2015)

MYO7A is an unconventional myosin involved in the structural organization of hair bundles at the apex of sensory hair cells (SHCs) where it serves mechanotransduction in the process of hearing and bal...

A newly designed molecule J2326 for Alzheimer's disease disaggregates amyloid fibrils and induces neurite outgrowth.

Neuropharmacology 92 , 146-57, (2015)

Alzheimer's disease is a neurodegenerative disorder characterized by deposition of β-amyloid (Aβ) fibrils accompanied with progressive neurite loss. None of the clinically approved anti-Alzheimer's ag...

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