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瑞替加滨

瑞替加滨用途

Retigabine is a novel anti-convulsant, enhances activation of KCNQ2/Q3 potassium channels.

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瑞替加滨名称

[ CAS 号 ]:
150812-12-7

[ 中文名 ]:
瑞替加滨

[ 英文名 ]:
Retigabine

[中文别名 ]:

[英文别名 ]:

Retigabine
Trobalt
Ezogabine
Potiga
EINECS 200-835-2

瑞替加滨物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
430.0±45.0 °C at 760 mmHg

[ 分子式 ]:
C₁₆H₁₈FN₃O₂

[ 分子量 ]:
303.331

[ 闪点 ]:
213.9±28.7 °C

[ 精确质量 ]:
303.138306

[ PSA ]:
76.38000

[ LogP ]:
0.81

[ 蒸汽压 ]:
0.0±1.0 mmHg at 25°C

[ 折射率 ]:
1.656

[ 储存条件 ]:
room temp

瑞替加滨MSDS

瑞替加滨安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H319-H413

[ 警示性声明 ]:
P305 + P351 + P338

[ 危害码 (欧洲) ]:
T,N,Xn,F,Xi

[ 风险声明 (欧洲) ]:
23-25-50/53-36-20/21/22-11

[ 安全声明 (欧洲) ]:
45-60-61-36/37-16-26

[ 危险品运输编码 ]:
NONH for all modes of transport

瑞替加滨合成路线

瑞替加滨文献

Enhanced in vitro CA1 network activity in a sodium channel β1(C121W) subunit model of genetic epilepsy.

Epilepsia 55(4) , 601-8, (2014)

A NaV β1(C121W) mouse model of human genetic epilepsy has enhanced neuronal excitability and temperature sensitivity attributed to a decreased threshold for action potential firing in the axon initial...

Safety profile of two novel antiepileptic agents approved for the treatment of refractory partial seizures: ezogabine (retigabine) and perampanel.

Expert Opin. Drug Saf. 12(6) , 847-55, (2013)

Complex-partial seizures are frequently resistant to antiepileptic therapy. Two new medications with mechanisms of action novel within the antiepileptic class have recently received approval for the a...

Ezogabine (retigabine) and its role in the treatment of partial-onset seizures: a review.

Clin. Ther. 34(9) , 1845-56.e1, (2012)

Ezogabine, also known as retigabine, is a recently approved anticonvulsant medication with a novel mechanism of action. It activates low-threshold voltage-gated potassium channels, leading to hyperpol...

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瑞替加滨

瑞替加滨用途

瑞替加滨名称

瑞替加滨物理化学性质

瑞替加滨MSDS

详细MSDS(安全技术说明书)

瑞替加滨安全信息

瑞替加滨合成路线

详细合成路线

瑞替加滨文献

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