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2-氨基-3-(5-氟-1H-吲哚-3-基)丙酸

2-氨基-3-(5-氟-1H-吲哚-3-基)丙酸名称

[ CAS 号 ]:
154-08-5

[ 中文名 ]:
5-氟-DL-色氨酸

[ 英文名 ]:
DL-5-Fluorotryptophan

[中文别名 ]:

5-氟色氨酸

[英文别名 ]:

2-amino-3-(5-fluoro-1H-indol-3-yl)propanoic acid
5-Fluoro-DL-tryptophan
H-5-FLUORO-DL-TRP-OH
5-Fluoro D,L-tryptophan
5-fluoro-DL-Trp
5-Fluoro-D,L-tryptophan
DL-5-FLUOROTRYPTOPHAN
MFCD00005649
EINECS 205-822-5
5-Fluorotryptophan

2-氨基-3-(5-氟-1H-吲哚-3-基)丙酸物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
450.7±45.0 °C at 760 mmHg

[ 熔点 ]:
265 °C (dec.)(lit.)

[ 分子式 ]:
C₁₁H₁₁FN₂O₂

[ 分子量 ]:
222.216

[ 闪点 ]:
226.4±28.7 °C

[ 精确质量 ]:
222.080460

[ PSA ]:
79.11000

[ LogP ]:
1.17

[ 外观性状 ]:
白色粉末

[ 蒸汽压 ]:
0.0±1.2 mmHg at 25°C

[ 折射率 ]:
1.673

[ 储存条件 ]:
2-8°C

2-氨基-3-(5-氟-1H-吲哚-3-基)丙酸MSDS

详细MSDS(安全技术说明书)

2-氨基-3-(5-氟-1H-吲哚-3-基)丙酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: YN6825000

CHEMICAL NAME :: Tryptophan, 5-fluoro-, DL-

CAS REGISTRY NUMBER :: 154-08-5

BEILSTEIN REFERENCE NO. :: 0022753

LAST UPDATED :: 199803

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C11-H11-F-N2-O2

MOLECULAR WEIGHT :: 222.24

WISWESSER LINE NOTATION :: T56 BMJ D1YZVQ GF

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 776 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 15,2134,1966

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2-氨基-3-(5-氟-1H-吲哚-3-基)丙酸安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi: Irritant;

[ 风险声明 (欧洲) ]:
R36/38

[ 安全声明 (欧洲) ]:
S22-S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
YN6825000

[ 海关编码 ]:
2933990090

2-氨基-3-(5-氟-1H-吲哚-3-基)丙酸上下游产品

2-氨基-3-(5-氟-1H-吲哚-3-基)丙酸上游产品

2-氨基-3-(5-氟-1H-吲哚-3-基)丙酸下游产品

2-氨基-3-(5-氟-1H-吲哚-3-基)丙酸海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

2-氨基-3-(5-氟-1H-吲哚-3-基)丙酸文献

Hydrophobic effect and hydrogen bonds account for the improved activity of a complement inhibitor, compstatin.

J. Med. Chem. 49(15) , 4616-22, (2006)

Tryptophans at positions 4 and 7 of compstatin, a peptide complement inhibitor, are crucial for its interaction with C3. However, the nature of their involvement has not been studied to date. Here we ...

Ionization potentials of fluoroindoles and the origin of nonexponential tryptophan fluorescence decay in proteins.

J. Am. Chem. Soc. 127(11) , 4104-13, (2005)

This work reports an explanation for the unusual monoexponential fluorescence decay of 5-fluorotryptophan (5FTrp) in single-Trp mutant proteins [Broos, J.; Maddalena, F.; Hesp, B. H. J. Am. Chem. Soc....

In vivo synthesized proteins with monoexponential fluorescence decay kinetics.

J. Am. Chem. Soc. 126(1) , 22-3, (2004)

Tryptophan, when in a protein, typically shows multiexponential fluorescence decay kinetics. Complex kinetics prevents a straightforward interpretation of time-resolved fluorescence protein data, part...

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