[R-(R,S)]-alpha-[2-(dimethylamino)-1-methylethyl]-alpha-phenylphenethyl propionate hydrochloride

用途

()-Propoxyphene hydrochloride is an analytical reference standard categorized as an opioid. This product is intended for research and forensic applications.

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名称

[ CAS 号 ]:
1596-70-9

[ 英文名 ]:
[R-(R*,S*)]-alpha-[2-(dimethylamino)-1-methylethyl]-alpha-phenylphenethyl propionate hydrochloride

[英文别名 ]:

D-propoxyphene
L-Propoxyphene hydrochloride
Levopropoxyphene HCl
Levopropoxyphene hydrochloride

物理化学性质

[ 沸点 ]:
444ºC at 760mmHg

[ 分子式 ]:
C₂₂H₃₀ClNO₂

[ 分子量 ]:
375.93200

[ 闪点 ]:
130.6ºC

[ 精确质量 ]:
375.19700

[ PSA ]:
29.54000

[ LogP ]:
5.07750

[ 蒸汽压 ]:
4.43E-08mmHg at 25°C

[ 储存条件 ]:
-20°C，密闭，干燥

毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: EL3050000

CHEMICAL NAME :: 2-Butanol, 4-(dimethylamino)-3-methyl-1,2-diphenyl-, propionate (ester), hydrochloride, (L)-

CAS REGISTRY NUMBER :: 1596-70-9

LAST UPDATED :: 199012

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C22-H29-N-O2.Cl-H

MOLECULAR WEIGHT :: 375.98

WISWESSER LINE NOTATION :: 2VOXR&1R&Y1&1N1&1 &GH -L

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 182 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: RPOBAR Research Progress in Organic-Biological and Medicinal Chemistry. (New York, NY) V.1-3, 1964-72. Discontinued. Volume(issue)/page/year: 2,320,1970

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 114 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia Lungs, Thorax, or Respiration - other changes

REFERENCE :: JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 63,451,1974

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 20 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: RPOBAR Research Progress in Organic-Biological and Medicinal Chemistry. (New York, NY) V.1-3, 1964-72. Discontinued. Volume(issue)/page/year: 2,319,1970