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2-硝酸异山梨酯

2-硝酸异山梨酯名称

[ CAS 号 ]:
16106-20-0

[ 中文名 ]:
2-硝酸异山梨酯(STORE BELOW +4 DEGR C)

[ 英文名 ]:
isosorbide 2-mononitrate

[中文别名 ]:

[英文别名 ]:

2-Ismn
Glucitol,1,4:3,6-dianhydro-,2-nitrate,D
1,4:3,6-Dianhydrosorbitol 2-mononitrate
Isosorbide-5-nitrate
isosorbide-5-mononitrate
Isosorbide 2-nitrate
Isosorbide-2-mononitrate
1,4:3,6-Dianhydro-D-glucitol 2-nitrate

2-硝酸异山梨酯物理化学性质

[ 密度 ]:
1.56g/cm3

[ 沸点 ]:
364.5ºC at 760mmHg

[ 熔点 ]:
>51.5°C

[ 分子式 ]:
C₆H₉NO₆

[ 分子量 ]:
191.13900

[ 闪点 ]:
174.2ºC

[ 精确质量 ]:
191.04300

[ PSA ]:
93.74000

[ 蒸汽压 ]:
8.66E-07mmHg at 25°C

[ 折射率 ]:
1.542

[ 储存条件 ]:
-20°C Freezer

2-硝酸异山梨酯MSDS

详细MSDS(安全技术说明书)

2-硝酸异山梨酯毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LZ4385500

CAS REGISTRY NUMBER :: 16106-20-0

LAST UPDATED :: 199206

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C6-H9-N-O6

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 33,1117,1983

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 33,1117,1983

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity)

REFERENCE :: KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 19,4947,1985

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2-硝酸异山梨酯安全信息

[ 危害码 (欧洲) ]:
F

[ RTECS号 ]:
LZ4385500

2-硝酸异山梨酯文献

Effects of isosorbide-5-mononitrate and isosorbide-2-mononitrate on isolated dog aorta: vascular relaxation and increase in cyclic GMP.

Arch. Int. Pharmacodyn. Ther. 312 , 104-9, (1991)

The effects of isosorbide-5-mononitrate (IS-5-MN) and isosorbide-2-mononitrate (IS-2-MN) on vascular smooth muscle tone and on cyclic nucleotide levels were studied in isolated dog aorta. The effects ...

Pharmacokinetic/pharmacodynamic relationship of the duration of vasodilating action of organic mononitrates in rats.

J. Pharmacol. Exp. Ther. 261(2) , 692-700, (1992)

Conflicting information existed regarding the relevance of pharmacokinetics in relation to the duration of action of organic nitrates. We examined this question using three geometric isomers of organi...

[Study of the bioequivalence of a new isosorbide dinitrate tablet formulation compared with the standard preparation].

Arzneimittelforschung 47(6) , 719-26, (1997)

An investigation in the bioequivalence of a new tablet formulation with 5 mg isosorbide dinitrate (CAS 87-33-2, ISDN 5 von ct) was performed in a two-way cross-over study with 18 subjects. The relativ...

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