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5-氨基-3-(4-吗啉基)-1,2,3-恶二唑盐酸盐

5-氨基-3-(4-吗啉基)-1,2,3-恶二唑盐酸盐用途

SIN-1(氯化物)是莫西多明的活性代谢产物。SIN-1(氯化物)具有强大的血管舒张作用和抑制血小板聚集[1]。在心肌缺血再灌注模型中,SIN-1(氯化物)可减少心肌坏死和再灌注诱导的内皮功能障碍[2]。

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5-氨基-3-(4-吗啉基)-1,2,3-恶二唑盐酸盐名称

[ CAS 号 ]:
16142-27-1

[ 中文名 ]:
5-氨基-3-(4-吗啉基)-1,2,3-恶二唑盐酸盐

[ 英文名 ]:
Linsidomine hydrochloride

[中文别名 ]:

林西多明盐酸盐

[英文别名 ]:

3-(4-morpholinyl)-5-sydnone imine hydrochloride
T6N DOTJ A- AT5KNOYJ DUM &&sydnone
SIN-I HYDROCHLORIDE
LINSIDOMINE HCL
3-(4-morpholinyl)-sydnonimine hydrochloride
MFCD00221615
3-(4-Morpholinyl)sydnone imine hydrochloride
LinsidoMine Chlorhydrate
3-morpholinosydnone imine hydrochloride
MolsidoMine IMpurity A

5-氨基-3-(4-吗啉基)-1,2,3-恶二唑盐酸盐生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 心血管疾病

[参考文献]

[1]. Nishikawa M,et al. Inhibition of platelet aggregation and stimulation of guanylate cyclase by an antianginal agent molsidomine and its metabolites. J Pharmacol Exp Ther. 1982 Jan;220(1):183-90.

[2]. Siegfried MR, et al. Cardioprotection and attenuation of endothelial dysfunction by organic nitric oxide donors in myocardial ischemia-reperfusion. J Pharmacol Exp Ther. 1992 Feb;260(2):668-75.

5-氨基-3-(4-吗啉基)-1,2,3-恶二唑盐酸盐物理化学性质

[ 熔点 ]:
186 °C

[ 分子式 ]:
C₆H₁₁ClN₄O₂

[ 分子量 ]:
206.630

[ 精确质量 ]:
206.057053

[ PSA ]:
67.28000

[ 外观性状 ]:
白色针状或略淡黄色白色结晶粉末

[ 储存条件 ]:
-20°C

[ 水溶解性 ]:
soluble

5-氨基-3-(4-吗啉基)-1,2,3-恶二唑盐酸盐MSDS

详细MSDS(安全技术说明书)

5-氨基-3-(4-吗啉基)-1,2,3-恶二唑盐酸盐毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: WU7687800

CHEMICAL NAME :: Sydnone imine, 3-morpholino-, monohydrochloride

CAS REGISTRY NUMBER :: 16142-27-1

LAST UPDATED :: 198910

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C6-H10-N4-O2.Cl-H

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 480 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 2,280,1968

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 315 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 2,280,1968

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 260 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 2,280,1968

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5-氨基-3-(4-吗啉基)-1,2,3-恶二唑盐酸盐安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 安全声明 (欧洲) ]:
S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ 海关编码 ]:
2934999090

5-氨基-3-(4-吗啉基)-1,2,3-恶二唑盐酸盐上下游产品

5-氨基-3-(4-吗啉基)-1,2,3-恶二唑盐酸盐上游产品

5-氨基-3-(4-吗啉基)-1,2,3-恶二唑盐酸盐下游产品

5-氨基-3-(4-吗啉基)-1,2,3-恶二唑盐酸盐制备

可用4-氨基吗啉先以氰化钾、甲醛氰甲基化，生成4-（氰甲基氨基）吗啉，然后以亚硝酸钠亚硝化得4-（氰甲基亚硝基氨基）吗啉，后者在盐酸甲醇中环合得到本品。

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5-氨基-3-(4-吗啉基)-1,2,3-恶二唑盐酸盐海关

[ 海关编码 ]: 2934999090

[ 中文概述 ]:
2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

5-氨基-3-(4-吗啉基)-1,2,3-恶二唑盐酸盐文献

Activated platelets rescue apoptotic cells via paracrine activation of EGFR and DNA-dependent protein kinase.

Cell Death Dis. 5 , e1410, (2014)

Platelet activation is a frontline response to injury, not only essential for clot formation but also important for tissue repair. Indeed, the reparative influence of platelets has long been exploited...

Taurine reduces nitrosative stress and nitric oxide synthase expression in high glucose-exposed human Schwann cells.

Exp. Neurol. 233(1) , 154-62, (2012)

The role of taurine in regulating glucose-induced nitrosative stress has been examined in human Schwann cells, a model for understanding the pathogenesis of diabetic neuropathy. Exposure to high gluco...

Comparative kinetics of thiol oxidation in two distinct free-radical generating systems: SIN-1 versus AAPH.

Free Radic. Res. 46(10) , 1190-200, (2012)

To study oxidative stress in biological systems, chemical compounds capable of producing free radicals have been widely used. Here, we compared two free-radical generators, 3-morpholinosydnonimine (SI...

更多文献

5-氨基-3-(4-吗啉基)-1,2,3-恶二唑盐酸盐

5-氨基-3-(4-吗啉基)-1,2,3-恶二唑盐酸盐用途

5-氨基-3-(4-吗啉基)-1,2,3-恶二唑盐酸盐名称

5-氨基-3-(4-吗啉基)-1,2,3-恶二唑盐酸盐生物活性

5-氨基-3-(4-吗啉基)-1,2,3-恶二唑盐酸盐物理化学性质

5-氨基-3-(4-吗啉基)-1,2,3-恶二唑盐酸盐MSDS

详细MSDS(安全技术说明书)

5-氨基-3-(4-吗啉基)-1,2,3-恶二唑盐酸盐毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

5-氨基-3-(4-吗啉基)-1,2,3-恶二唑盐酸盐安全信息

5-氨基-3-(4-吗啉基)-1,2,3-恶二唑盐酸盐上下游产品

5-氨基-3-(4-吗啉基)-1,2,3-恶二唑盐酸盐上游产品

5-氨基-3-(4-吗啉基)-1,2,3-恶二唑盐酸盐下游产品

5-氨基-3-(4-吗啉基)-1,2,3-恶二唑盐酸盐制备

5-氨基-3-(4-吗啉基)-1,2,3-恶二唑盐酸盐海关

5-氨基-3-(4-吗啉基)-1,2,3-恶二唑盐酸盐文献

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