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腺苷-5'-二磷酸钠盐水合物

腺苷-5'-二磷酸钠盐水合物用途

5'-二磷酸腺苷二钠是一种二磷酸核苷。腺苷5'-二磷酸二钠是ATP酶进行ATP去磷酸化的产物。腺苷5'-二磷酸二钠是一种血小板聚集剂,用于止血和动脉血栓形成的发展和扩展[1][2]。

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腺苷-5'-二磷酸钠盐水合物名称

[ CAS 号 ]:
16178-48-6

[ 中文名 ]:
腺苷-5'-二磷酸二钠盐

[ 英文名 ]:
Adenosine-5'-diphosphate disodium salt

[中文别名 ]:

[英文别名 ]:

Adenosine 5'-Diphosphate Disodium Salt Hydrate
EINECS 240-314-7
adenosine diphosphate sodium salt
Adenosine 5′-diphosphate disodium salt
5'-ADP-Na2
Adenosine 5'-diphosphate disodium salt
5'-ADP Na Hydrate
Adenosine 5‘-diphosphate,disodium salt hydrate
MFCD00066635
Adenosine-5'-diphosphatedisodiumsalt

腺苷-5'-二磷酸钠盐水合物生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 心血管疾病

[ 靶点 ]

Human Endogenous Metabolite

[体外研究]

5'-二磷酸腺苷二钠(10μmol/L)诱导人血小板聚集以及血小板,第10页细胞和第2页第1页转染细胞中的 [Ca2+]i的增加[1]。 5'-二磷酸腺苷二钠(5μmol/L)可提高人血小板和第10页细胞中营地的水平[1]。

[参考文献]

[1]. Hechler B, et al. The P2Y1 receptor is necessary for adenosine 5'-diphosphate-induced platelet aggregation. Blood. 1998 Jul 1;92(1):152-9.

[2]. Arts IC, et al. Adenosine 5'-triphosphate (ATP) supplements are not orally bioavailable: a randomized, placebo-controlled cross-over trial in healthy humans. J Int Soc Sports Nutr. 2012 Apr 17;9(1):16.

腺苷-5'-二磷酸钠盐水合物物理化学性质

[ 沸点 ]:
877.7ºC at 760 mmHg

[ 分子式 ]:
C₁₀H₁₃N₅Na₂O₁₀P₂

[ 分子量 ]:
471.165

[ 闪点 ]:
484.6ºC

[ 精确质量 ]:
470.993317

[ PSA ]:
257.88000

[ 外观性状 ]:
白色至灰白色粉末

[ 储存条件 ]:
−20°C

腺苷-5'-二磷酸钠盐水合物MSDS

详细MSDS(安全技术说明书)

腺苷-5'-二磷酸钠盐水合物安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S22-S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

腺苷-5'-二磷酸钠盐水合物文献

A novel surface-confined glucaminium-based ionic liquid stationary phase for hydrophilic interaction/anion-exchange mixed-mode chromatography.

J. Chromatogr. A. 1360 , 240-7, (2014)

Glucaminium-based ionic liquids are a new class of recently developed ionic liquids and prepared by functionalizing the amine group of N-methyl-d-glucamine, which renders them good hydrophilicity due ...

Adenosine derived from ADP can contribute to inhibition of platelet aggregation in the presence of a P2Y12 antagonist.

Arterioscler. Thromb. Vasc. Biol. 31 , 416-422, (2011)

To investigate whether adenosine diphosphate (ADP)-derived adenosine might inhibit platelet aggregation, especially in the presence of a P2Y₁₂ antagonist, where the effects of ADP at the P2Y₁₂ recepto...

Extracellular Ca(2+) modulates ADP-evoked aggregation through altered agonist degradation: implications for conditions used to study P2Y receptor activation.

Br. J. Haematol. 153 , 83-91, (2011)

ADP is considered a weak platelet agonist due to the limited aggregation responses it induces in vitro at physiological concentrations of extracellular Ca(2+) [(Ca(2+) )(o) ]. Lowering [Ca(2+) ](o) pa...

更多文献

腺苷-5'-二磷酸钠盐水合物

腺苷-5'-二磷酸钠盐水合物用途

腺苷-5'-二磷酸钠盐水合物名称

腺苷-5'-二磷酸钠盐水合物生物活性

腺苷-5'-二磷酸钠盐水合物物理化学性质

腺苷-5'-二磷酸钠盐水合物MSDS

详细MSDS(安全技术说明书)

腺苷-5'-二磷酸钠盐水合物安全信息

腺苷-5'-二磷酸钠盐水合物文献

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