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2,4',5-三氯联苯

2,4',5-三氯联苯名称

[ CAS 号 ]:
16606-02-3

[ 中文名 ]:
2,4,5-三氯联苯醚

[ 英文名 ]:
2,4',5-Trichlorobiphenyl

[中文别名 ]:

[英文别名 ]:

1,4-dichloro-2-(4-chlorophenyl)benzene
MFCD00078742
1,1'-Biphenyl, 2,4',5-trichloro-
2,4',5-Trichlorobiphenyl
2,4',5-Trichlorobiphényl

2,4',5-三氯联苯物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
331.5±27.0 °C at 760 mmHg

[ 熔点 ]:
67℃

[ 分子式 ]:
C₁₂H₇Cl₃

[ 分子量 ]:
257.543

[ 闪点 ]:
227.3±19.3 °C

[ 精确质量 ]:
255.961334

[ LogP ]:
5.52

[ 蒸汽压 ]:
0.0±0.7 mmHg at 25°C

[ 折射率 ]:
1.604

[ 储存条件 ]:
室温

2,4',5-三氯联苯毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DV8810000

CHEMICAL NAME :: Biphenyl, 2,4',5-trichloro-

CAS REGISTRY NUMBER :: 16606-02-3

BEILSTEIN REFERENCE NO. :: 1961529

LAST UPDATED :: 199710

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C12-H7-Cl3

MOLECULAR WEIGHT :: 257.54

WISWESSER LINE NOTATION :: GR BG DR BG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 150 mg/kg/3D-I

TOXIC EFFECTS :: Liver - changes in liver weight Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other esterases Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 33,94,1975

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Primate - monkey

DOSE/DURATION :: 21 mg/kg/84D-C

TOXIC EFFECTS :: Brain and Coverings - other degenerative changes Brain and Coverings - changes in brain weight Liver - changes in liver weight

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 41,629,1977 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 120 mg/kg

SEX/DURATION :: female 1-6 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea)

REFERENCE :: APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH Volume(issue)/page/year: 42,323,1978

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 78 mg/kg

SEX/DURATION :: female 5-21 day(s) after conception lactating female 22 day(s) post-birth

TOXIC EFFECTS :: Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)

REFERENCE :: APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH Volume(issue)/page/year: 42,275,1978 *** REVIEWS *** TOXICOLOGY REVIEW EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972- Volume(issue)/page/year: 24,173,1978

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2,4',5-三氯联苯安全信息

[ 符号 ]:

GHS08, GHS09

[ 信号词 ]:
Warning

[ 危害声明 ]:
H373-H410

[ 警示性声明 ]:
P273-P391-P501

[ 危害码 (欧洲) ]:
N: Dangerous for the environment;

[ 风险声明 (欧洲) ]:
R33

[ 安全声明 (欧洲) ]:
S35

[ 危险品运输编码 ]:
UN 3432 9/PG 2

[ RTECS号 ]:
DV8810000

[ 海关编码 ]:
2903999090

2,4',5-三氯联苯合成路线

详细合成路线

2,4',5-三氯联苯海关

[ 海关编码 ]: 2903999090

[ 中文概述 ]:
2903999090 其他芳烃卤化衍生物. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:5.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2903999090 halogenated derivatives of aromatic hydrocarbons VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

2,4',5-三氯联苯文献

Liver cell cytoplasmic inclusions in experimental porphyrias: their demonstration with the ferric ferricyanide reduction reaction.

Exp. Toxicol. Pathol. 49(3-4) , 289-93, (1997)

In the present paper we describe needle-shaped and granular cytoplasmic inclusions in the liver cells of mice and rats with experimental porphyria biochemically resembling human porphyria cutanea tard...

Alteration of regiospecificity in biphenyl dioxygenase by active-site engineering.

J. Bacteriol. 184(13) , 3682-8, (2002)

Biphenyl dioxygenase (Bph Dox) is responsible for the initial dioxygenation step during the metabolism of biphenyl. The large subunit (BphA1) of Bph Dox plays a crucial role in the determination of th...

Impacts of molt-inhibiting organochlorine compounds on epidermal ecdysteroid signaling in the fiddler crab, Uca pugilator, in vitro.

Comp. Biochem. Physiol. C. Toxicol. Pharmacol. 150(4) , 436-41, (2009)

Because of their chemical stability and lipophilicity, many organochlorine compounds (OCs) can readily accumulate in fatty tissues of crustaceans. Several OCs have been reported to inhibit crustacean ...

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