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5-甲氧基芦竹碱

5-甲氧基芦竹碱名称

[ CAS 号 ]:
16620-52-3

[ 中文名 ]:
5-甲氧基芦竹碱

[ 英文名 ]:
5-METHOXYGRAMINE

[中文别名 ]:

5-甲氧基-3-二甲胺基甲基吲哚

[英文别名 ]:

EINECS 240-669-8
5-METHOXYGRAMINE
MFCD00005630

5-甲氧基芦竹碱物理化学性质

[ 密度 ]:
1.119g/cm3

[ 沸点 ]:
334.7ºC at 760 mmHg

[ 熔点 ]:
123-126 °C(lit.)

[ 分子式 ]:
C₁₂H₁₆N₂O

[ 分子量 ]:
204.26800

[ 闪点 ]:
156.2ºC

[ 精确质量 ]:
204.12600

[ PSA ]:
28.26000

[ LogP ]:
2.23810

[ 外观性状 ]:
白色至近乎于白色结晶粉末

[ 蒸汽压 ]:
0.000126mmHg at 25°C

[ 储存条件 ]:
Refrigerator (+4°C)

5-甲氧基芦竹碱MSDS

5-甲氧基芦竹碱毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NL7700000

CHEMICAL NAME :: Indole, 3-((dimethylamino)methyl)-5-methoxy-

CAS REGISTRY NUMBER :: 16620-52-3

BEILSTEIN REFERENCE NO. :: 0170533

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C12-H16-N2-O

MOLECULAR WEIGHT :: 204.30

WISWESSER LINE NOTATION :: T56 BMJ D1N1&1 GO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 130 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PSYPAG Psychopharmacologia (Berlin). (Berlin, Ger.) V.1-46, 1959-76. For publisher information, see PSCHDL. Volume(issue)/page/year: 16,385,1970

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 56 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#04863

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5-甲氧基芦竹碱安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
C: Corrosive;

[ 风险声明 (欧洲) ]:
R34

[ 安全声明 (欧洲) ]:
S22-S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
NL7700000

[ 海关编码 ]:
2933990090

5-甲氧基芦竹碱合成路线

5-甲氧基芦竹碱海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

5-甲氧基芦竹碱文献

Regulation of serotonin 5-HT2C receptors by chronic ligand exposure.

Eur. J. Pharmacol. 498(1-3) , 59-69, (2004)

The effect of ligand pretreatment on human 5-hydroxytryptamine2C (5-HT2C) receptors was examined in CHO cells expressing high (CHO-1C7; 67+/-3 pmol/mg) or low (CHO-1C19; 72+/-10 fmol/mg) levels of the...

Kinetics of competitive drug action at 5-hydroxytryptamine2 receptors in isolated rabbit aorta.

J. Pharmacol. Exp. Ther. 242(1) , 108-14, (1987)

The kinetics of agonist and antagonist interactions with the 5-hydroxytryptamine2 receptor were studied in the isolated rabbit aorta by following the antagonist-induced decrease in the steady-state re...

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