4-羟基-3,5-二碘苯腈
4-羟基-3,5-二碘苯腈用途
4-羟基-3,5-二碘苯腈名称
[ CAS 号 ]:
1689-83-4
[ 中文名 ]:
碘苯腈
[ 英文名 ]:
IOXYNIL
[中文别名 ]:
[英文别名 ]:
- Joxynil
- Benzonitrile, 4-hydroxy-3,5-diiodo-
- 3,5-diiodo-4-hydroxy-benzonitrile
- 2,6-Diiodo-4-cyanophenol
- Cipotril
- UNII:8Y734M4V9E
- MFCD00016422
- Benzonitrile,4-hydroxy-3,5-diiodo
- EINECS 216-881-1
- 4-Hydroxy-3,5-diiodobenzonitrile
4-羟基-3,5-二碘苯腈物理化学性质
[ 密度 ]:
2.7±0.1 g/cm3
[ 沸点 ]:
282.6±40.0 °C at 760 mmHg
[ 熔点 ]:
200 °C
[ 分子式 ]:
C7H3I2NO
[ 分子量 ]:
370.914
[ 闪点 ]:
124.7±27.3 °C
[ 精确质量 ]:
370.830383
[ PSA ]:
44.02000
[ LogP ]:
3.60
[ 外观性状 ]:
米色非晶形的粉末
[ 蒸汽压 ]:
0.0±0.6 mmHg at 25°C
[ 折射率 ]:
1.805
[ 储存条件 ]:
库房通风低温干燥,与食品原料分开储运
[ 水溶解性 ]:
不溶
4-羟基-3,5-二碘苯腈MSDS
4-羟基-3,5-二碘苯腈毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- DI4025000
- CHEMICAL NAME :
- Benzonitrile, 3,5-diiodo-4-hydroxy-
- CAS REGISTRY NUMBER :
- 1689-83-4
- BEILSTEIN REFERENCE NO. :
- 2364041
- LAST UPDATED :
- 199712
- DATA ITEMS CITED :
- 20
- MOLECULAR FORMULA :
- C7-H3-I2-N-O
- MOLECULAR WEIGHT :
- 370.91
- WISWESSER LINE NOTATION :
- QR BI FI DCN
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human
- DOSE/DURATION :
- 28 mg/kg
- TOXIC EFFECTS :
- Brain and Coverings - other degenerative changes Lungs, Thorax, or Respiration - acute pulmonary edema Blood - hemorrhage
- REFERENCE :
- ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974- Volume(issue)/page/year: 37,241,1977
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 110 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- WRPCA2 World Review of Pest Control. (London, UK) V.1-10, 1962-71. Discontinued. Volume(issue)/page/year: 9,119,1970
- TYPE OF TEST :
- LC50 - Lethal concentration, 50 percent kill
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >3 gm/m3/6H
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 85JFAN "Agrochemicals Handbook," with updates, Hartley, D., and H. Kidd, eds., Nottingham, Royal Soc. of Chemistry, 1983-86 Volume(issue)/page/year: A233,1983
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 210 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- GUCHAZ Guide to the Chemicals Used in Crop Protection. (Information Canada, 171 Slater St., Ottawa, Ont., Canada) Volume(issue)/page/year: 6,304,1973
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 230 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 85GYAV "Pflanzenschutz-und Schaedlingsbekaempfungsmittel: Abriss einer Toxikologie und Therapie von Vergiftungen," 2nd ed., Klimmer, O.R., Hattingen, Fed. Rep. Ger., Hundt-Verlag, 1971 Volume(issue)/page/year: -,93,1971
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 56 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#02818
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Unreported
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 230 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- GUCHAZ Guide to the Chemicals Used in Crop Protection. (Information Canada, 171 Slater St., Ottawa, Ont., Canada) Volume(issue)/page/year: 6,304,1973
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - cat
- DOSE/DURATION :
- 75 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 85GYAV "Pflanzenschutz-und Schaedlingsbekaempfungsmittel: Abriss einer Toxikologie und Therapie von Vergiftungen," 2nd ed., Klimmer, O.R., Hattingen, Fed. Rep. Ger., Hundt-Verlag, 1971 Volume(issue)/page/year: -,93,1971
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 180 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 85GYAV "Pflanzenschutz-und Schaedlingsbekaempfungsmittel: Abriss einer Toxikologie und Therapie von Vergiftungen," 2nd ed., Klimmer, O.R., Hattingen, Fed. Rep. Ger., Hundt-Verlag, 1971 Volume(issue)/page/year: -,93,1971
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Unreported
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 180 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- GUCHAZ Guide to the Chemicals Used in Crop Protection. (Information Canada, 171 Slater St., Ottawa, Ont., Canada) Volume(issue)/page/year: 6,304,1973
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 76 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 85GYAV "Pflanzenschutz-und Schaedlingsbekaempfungsmittel: Abriss einer Toxikologie und Therapie von Vergiftungen," 2nd ed., Klimmer, O.R., Hattingen, Fed. Rep. Ger., Hundt-Verlag, 1971 Volume(issue)/page/year: -,93,1971
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Bird - chicken
- DOSE/DURATION :
- 200 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 85GYAV "Pflanzenschutz-und Schaedlingsbekaempfungsmittel: Abriss einer Toxikologie und Therapie von Vergiftungen," 2nd ed., Klimmer, O.R., Hattingen, Fed. Rep. Ger., Hundt-Verlag, 1971 Volume(issue)/page/year: -,93,1971
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Unreported
- SPECIES OBSERVED :
- Mammal - species unspecified
- DOSE/DURATION :
- 120 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 30ZDA9 "Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag New York, Inc., 1971 Volume(issue)/page/year: -,149,1971
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Bird - wild bird species
- DOSE/DURATION :
- 75 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year: 9,496,1991 ** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 980 mg/kg/14W-C
- TOXIC EFFECTS :
- Liver - fatty liver degeneration Kidney, Ureter, Bladder - changes in bladder weight Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphatases
- REFERENCE :
- NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) V.1- 1976- Volume(issue)/page/year: 16,349,1991
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 21900 mg/kg/2Y-C
- TOXIC EFFECTS :
- Liver - changes in liver weight Nutritional and Gross Metabolic - weight loss or decreased weight gain Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphatases
- REFERENCE :
- NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) V.1- 1976- Volume(issue)/page/year: 16,349,1991
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 980 mg/kg/14W-C
- TOXIC EFFECTS :
- Lungs, Thorax, or Respiration - chronic pulmonary edema Lungs, Thorax, or Respiration - changes in lung weight Liver - changes in liver weight
- REFERENCE :
- NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) V.1- 1976- Volume(issue)/page/year: 16,349,1991
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1365 mg/kg/78W-C
- TOXIC EFFECTS :
- Gastrointestinal - other changes Liver - other changes
- REFERENCE :
- NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) V.1- 1976- Volume(issue)/page/year: 16,349,1991 ** TUMORIGENIC DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 6552 mg/kg/78W-C
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors
- REFERENCE :
- NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0571274
4-羟基-3,5-二碘苯腈安全信息
[ 符号 ]:
GHS06, GHS08, GHS09
[ 信号词 ]:
Danger
[ 危害声明 ]:
H301 + H331-H312-H319-H361d-H373-H410
[ 警示性声明 ]:
P201-P261-P273-P280-P301 + P310 + P330-P304 + P340 + P312
[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges
[ 危害码 (欧洲) ]:
T:Toxic;N:Dangerousfortheenvironment;
[ 风险声明 (欧洲) ]:
R21;R23/25;R36;R48/22;R50/53;R63
[ 安全声明 (欧洲) ]:
S61-S60-S45-S36/37-S63
[ 危险品运输编码 ]:
3276
[ RTECS号 ]:
DI4025000
[ 包装等级 ]:
III
[ 危险类别 ]:
6.1
[ 海关编码 ]:
2926909032
4-羟基-3,5-二碘苯腈合成路线
4-羟基-3,5-二碘苯腈上下游产品
4-羟基-3,5-二碘苯腈上游产品
4-羟基-3,5-二碘苯腈下游产品
4-羟基-3,5-二碘苯腈制备
以对羟基苯甲醛与碘作用,生成物再与羟胺反应生成相应的肟,用乙酸酐脱水生成产品。
4-羟基-3,5-二碘苯腈海关
[ 海关编码 ]: 2926909032
[ 中文概述 ]:
2926909032 杀螟腈、甲基辛硫磷等〔包括敌草腈、碘苯腈、辛酰碘苯腈、溴苯腈、辛酰溴苯腈〕。监管条件:S(进出口农药登记证明)。增值税率:17.0%。退税率:9.0%。最低关税:6.5%。普通关税:30.0%
[ 申报要素 ]: 品名, 成分含量, 用途
[ 监管条件 ]: S.进出口农药登记证明
[ Summary ]:
2926909032 o-(4-cyanophenyl) o,o-dimethyl phosphorothioate。supervision conditions:s(import or export registration certificate for pesticides)。VAT:17.0%。tax rebate rate:9.0%。MFN tarrif:6.5%。general tariff:30.0%
4-羟基-3,5-二碘苯腈文献
Environ. Pollut. 154(2) , 155-68, (2008)
The benzonitriles dichlobenil, bromoxynil and ioxynil are important broad-spectrum or selective herbicides used in agriculture, orchards and public areas worldwide. The dichlobenil metabolite 2,6-dich...
High-performance liquid chromatographic study of the aromatic nitrile metabolism in soil bacteria.J. Chromatogr. B, Biomed. Appl. 681(1) , 191-5, (1996)
Simultaneous HPLC determination of bromoxynil, ioxynil and dichlobenil, three arylnitrile herbicides, and their metabolic products in soil extracts and microbiological media is described. Limits of de...
The effect of endocrine disrupting chemicals on thyroid hormone binding to Japanese quail transthyretin and thyroid hormone receptor.Gen. Comp. Endocrinol. 134(1) , 36-43, (2003)
We investigated the effect of endocrine disrupting chemicals (EDCs), including medical, industrial, and agricultural chemicals, on 3,3',5-L-[125I]triiodothyronine ([125I]T3) binding to purified Japane...
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价格:
¥346.0/100mg
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