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酪氨酸磷酸化抑制剂AG1478

酪氨酸磷酸化抑制剂AG1478用途

酪氨酸磷酸化抑制剂AG 1478已用作表皮生长因子受体(EGFR)酪氨酸激酶抑制剂，用于研究其在boyden小室迁移检测中对硬纤维瘤细胞迁移的影响。它还用于抑制A431表皮样癌细胞株中外源性转化生长因子α介导的磷酸化。

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酪氨酸磷酸化抑制剂AG1478名称

[ CAS 号 ]:
175178-82-2

[ 中文名 ]:
酪氨酸磷酸化抑制剂AG1478

[ 英文名 ]:
Tyrphostin AG 1478

[中文别名 ]:

4-(3-氯苯胺)-6,7-二甲氧基喹唑啉

[英文别名 ]:

n-(3-chlorphenyl)-6,7-dimethoxy-4-chinazolinamin
Tyrphostin AG 1478
4-(3-Chloro-benzyl)-6,7-dimethoxy-quinazoline
MFCD00270914
N-(3-Chlorophenyl)-6,7-dimethoxyquinazolin-4-amine

酪氨酸磷酸化抑制剂AG1478物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
458.5±45.0 °C at 760 mmHg

[ 分子式 ]:
C₁₆H₁₄ClN₃O₂

[ 分子量 ]:
315.754

[ 闪点 ]:
231.1±28.7 °C

[ 精确质量 ]:
315.077454

[ PSA ]:
56.27000

[ LogP ]:
3.77

[ 外观性状 ]:
白色固体

[ 蒸汽压 ]:
0.0±1.1 mmHg at 25°C

[ 折射率 ]:
1.668

[ 储存条件 ]:
2-8°C

[ 水溶解性 ]:
0.1 M HCl: soluble <0.4 mg/mL

酪氨酸磷酸化抑制剂AG1478MSDS

详细MSDS(安全技术说明书)

酪氨酸磷酸化抑制剂AG1478安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

酪氨酸磷酸化抑制剂AG1478文献

HuR mediates the synergistic effects of angiotensin II and IL-1β on vascular COX-2 expression and cell migration.

Br. J. Pharmacol. 172 , 3028-42, (2015)

Angiotensin II (AngII) and IL-1β are involved in cardiovascular diseases through the induction of inflammatory pathways. HuR is an adenylate- and uridylate-rich element (ARE)-binding protein involved ...

Regulatory volume increase in astrocytes exposed to hypertonic medium requires β1 -adrenergic Na(+) /K(+) -ATPase stimulation and glycogenolysis.

J. Neurosci. Res. 93(1) , 130-9, (2014)

The cotransporter of Na(+) , K(+) , 2Cl(-) , and water, NKKC1, is activated under two conditions in the brain, exposure to highly elevated extracellular K(+) concentrations, causing astrocytic swellin...

Role of protein kinase C and epidermal growth factor receptor signalling in growth stimulation by neurotensin in colon carcinoma cells.

BMC Cancer 11 , 421, (2011)

Neurotensin has been found to promote colon carcinogenesis in rats and mice, and proliferation of human colon carcinoma cell lines, but the mechanisms involved are not clear. We have examined signalli...

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