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1,2-二氨基蒽醌

1,2-二氨基蒽醌用途

1,2-二氨基蒽醌是一种灵敏、特异、无毒的一氧化氮(NO)荧光探针。1,2-二氨基蒽醌可用于检测活细胞和动物中的NO生成,最大吸收波长约为540nm,NO的检测限为5μM[1][2]。

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1,2-二氨基蒽醌名称

[ CAS 号 ]:
1758-68-5

[ 中文名 ]:
1,2-二氨基蒽醌

[ 英文名 ]:
1,2-DIAMINOANTHRAQUINONE

[中文别名 ]:

[英文别名 ]:

EINECS 217-156-2
1,2-diamino-9,10-anthraquinone
1,2-diaminoanthracene-9,10-dione
1,2-diamino-anthraquinon
DAA
MFCD00001219
1,2-Diaminoanthraquinone
1,2-diamino-10-anthracenedione
diamino-anthraquinone
10-Anthracenedione,1,2-diamino-9

1,2-二氨基蒽醌生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[体外研究]

1,2-二氨基蒽醌及其与NO、DAA-TZ反应生成的产物可以使用荧光光谱和共焦显微镜进行光谱解析[1]。免疫荧光[1]细胞系：原始264.7巨噬细胞浓度：27.4μM孵育时间：20分钟结果：在细胞内有氧环境中与NO反应生成DAA-TZ。

[参考文献]

[1]. María J Marín, et al. Fluorescence of 1,2-diaminoanthraquinone and its nitric oxide reaction product within macrophage cells. Chembiochem. 2011 Nov 4;12(16):2471-7.

[2]. Francisco Galindo, et al. Spectroscopic studies of 1,2-diaminoanthraquinone (DAQ) as a fluorescent probe for the imaging of nitric oxide in living cells. Photochem Photobiol Sci. 2008 Jan;7(1):126-30.

1,2-二氨基蒽醌物理化学性质

[ 密度 ]:
1.456 g/cm3

[ 沸点 ]:
548.8ºC at 760 mmHg

[ 熔点 ]:
289-291 °C(lit.)

[ 分子式 ]:
C₁₄H₁₀N₂O₂

[ 分子量 ]:
238.24100

[ 闪点 ]:
285.7ºC

[ 精确质量 ]:
238.07400

[ PSA ]:
86.18000

[ LogP ]:
2.78880

[ 蒸汽压 ]:
4.26E-12mmHg at 25°C

[ 折射率 ]:
1.757

[ 储存条件 ]:
室温

1,2-二氨基蒽醌毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CB6200000

CHEMICAL NAME :: Anthraquinone, 1,2-diamino-

CAS REGISTRY NUMBER :: 1758-68-5

BEILSTEIN REFERENCE NO. :: 2125604

LAST UPDATED :: 199701

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C14-H10-N2-O2

MOLECULAR WEIGHT :: 238.26

WISWESSER LINE NOTATION :: L C666 BV IVJ DZ EZ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2700 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 320 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Salmonella typhimurium

DOSE/DURATION :: 100 ug/plate

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 40,203,1976

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1,2-二氨基蒽醌安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi: Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S37/39

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
CB6200000

[ 海关编码 ]:
2922399090

1,2-二氨基蒽醌合成路线

详细合成路线

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1,2-二氨基蒽醌海关

[ 海关编码 ]: 2922399090

[ 中文概述 ]:
2922399090 其他氨基醛、氨基酮及其盐（包括氨基醌及其盐，但含有一种以上含氧基的除外）. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装

[ Summary ]:
2922399090 other amino-aldehydes, amino-ketones and amino-quinones, other than those containing more than one kind of oxygen function; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

1,2-二氨基蒽醌文献

[Detection of NO-synthase activity of lactobacilli by fluorescent staining].

Mikrobiologiia 76(4) , 570-2, (2007)

Spatial nitric oxide imaging using 1,2-diaminoanthraquinone to investigate the involvement of nitric oxide in long-term potentiation in rat brain slices.

Neuroimage 15(3) , 633-9, (2002)

Long-term potentiation (LTP), a model of activity-dependent synaptic plasticity, involves the persistent enhancement of excitatory neurotransmission. Several recent studies have suggested a critical r...

Floral transition and nitric oxide emission during flower development in Arabidopsis thaliana is affected in nitrate reductase-deficient plants.

Plant Cell Physiol. 49(7) , 1112-21, (2008)

The nitrate reductase (NR)-defective double mutant of Arabidopsis thaliana (nia1 nia2) has previously been shown to present a low endogenous content of NO in its leaves compared with the wild-type pla...

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