(R,S)-降烟碱

(R,S)-降烟碱名称

[ CAS 号 ]:
17708-87-1

[ 中文名 ]:
(R,S)-降烟碱-2-氧化物

[ 英文名 ]:
(R,S)-Norcotinine

[中文别名 ]:

5-(吡啶-3-基)吡咯烷-2-酮

[英文别名 ]:

Demethylcotinine
5-(pyridin-3-yl)-pyrrolidin-2-one
(R,S)-Norcotinine
(+-)-5-[3]pyridyl-pyrrolidin-2-one
5-(3-Pyridinyl)-2-pyrrolidinone
5-(pyridin-3-yl)pyrrolidin-2-one
(+-)-5-[3]Pyridyl-pyrrolidin-2-on
2-Pyrrolidinone, 5-(3-pyridinyl)-
norcotinine

(R,S)-降烟碱物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
398.2±35.0 °C at 760 mmHg

[ 熔点 ]:
108-109ºC

[ 分子式 ]:
C₉H₁₀N₂O

[ 分子量 ]:
162.189

[ 闪点 ]:
194.6±25.9 °C

[ 精确质量 ]:
162.079315

[ PSA ]:
41.99000

[ LogP ]:
-1.00

[ 蒸汽压 ]:
0.0±0.9 mmHg at 25°C

[ 折射率 ]:
1.554

[ 储存条件 ]:
-20°C Freezer, Under Inert Atmosphere

(R,S)-降烟碱安全信息

[ 符号 ]:

GHS02, GHS06, GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H225-H301 + H311 + H331-H370

[ 警示性声明 ]:
P210-P260-P280-P301 + P310-P311

[ 危害码 (欧洲) ]:
F,T

[ 风险声明 (欧洲) ]:
11-23/24/25-39/23/24/25

[ 安全声明 (欧洲) ]:
16-36/37-45

[ 危险品运输编码 ]:
UN1230 - class 3 - PG 2 - Methanol, solution

(R,S)-降烟碱合成路线

详细合成路线

(R,S)-降烟碱上下游产品

(R,S)-降烟碱上游产品

(R,S)-降烟碱下游产品

(R,S)-降烟碱文献

Determination of nicotine and four metabolites in the serum of smokers by high-performance liquid chromatography with ultraviolet detection.

J. Chromatogr. A. 621(2) , 257-61, (1993)

A simple and reliable reversed-phase high-performance liquid chromatographic method with ultraviolet detection is described for the quantitation of nicotine and its metabolites cotinine, trans-3'-hydr...

Meconium nicotine and metabolites by liquid chromatography-tandem mass spectrometry: differentiation of passive and nonexposure and correlation with neonatal outcome measures.

Clin. Chem. 54(12) , 2018-27, (2008)

Meconium analysis is a diagnostically sensitive and objective alternative to maternal self-report for detecting prenatal tobacco exposure. Nicotine and metabolite disposition in meconium is poorly cha...

Quantification of nicotine, cotinine, trans-3'-hydroxycotinine, nornicotine and norcotinine in human meconium by liquid chromatography/tandem mass spectrometry.

J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 863(1) , 107-14, (2008)

There are no analytical methods that simultaneously quantify nicotine, cotinine, trans-3'-hydroxycotinine, nornicotine and norcotinine in human meconium. Such a method could improve identification of ...

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