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7-羟基华法林

7-羟基华法林用途

7-羟基华法林是一种具有抗凝血活性的华法林类似物[1]。

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7-羟基华法林名称

[ CAS 号 ]:
17834-03-6

[ 中文名 ]:
7-羟基华法林

[ 英文名 ]:
7-hydroxy Warfarin

[英文别名 ]:

7-Hydroxywarfarin
4,7-dihydroxy-3-(3-oxo-1-phenylbutyl)chromen-2-one

7-羟基华法林生物活性

[ 描述 ]:

7-羟基华法林是一种具有抗凝血活性的华法林类似物[1]。

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[参考文献]

[1]. Obaseki AO, Coker HB. The anticoagulant activity of some selected warfarin analogues. J Pharm Pharmacol. 1987 Feb;39(2):142-4.

7-羟基华法林物理化学性质

[ 密度 ]:
1.384g/cm3

[ 沸点 ]:
540.2ºC at 760mmHg

[ 熔点 ]:
220ºC

[ 分子式 ]:
C₁₉H₁₆O₅

[ 分子量 ]:
324.33

[ 闪点 ]:
197.7ºC

[ 精确质量 ]:
324.10000

[ PSA ]:
87.74000

[ LogP ]:
3.31520

[ 蒸汽压 ]:
1.68E-12mmHg at 25°C

[ 折射率 ]:
1.658

[ 储存条件 ]:
2~8℃，干燥，密封

7-羟基华法林MSDS

7-羟基华法林安全信息

[ 符号 ]:

GHS05, GHS07

[ 信号词 ]:
Danger

[ 危害声明 ]:
H302-H318

[ 警示性声明 ]:
P280-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ 危害码 (欧洲) ]:
Xn: Harmful;

[ 风险声明 (欧洲) ]:
R22

[ 安全声明 (欧洲) ]:
S26

[ 危险品运输编码 ]:
NONH for all modes of transport

[ 海关编码 ]:
2932209090

7-羟基华法林合成路线

7-羟基华法林上下游产品

7-羟基华法林上游产品

7-羟基华法林下游产品

7-羟基华法林海关

[ 海关编码 ]: 2932209090

[ 中文概述 ]:
2932209090. 其他内酯. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2932209090. other lactones. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

7-羟基华法林文献

Novel Marmoset Cytochrome P450 2C19 in Livers Efficiently Metabolizes Human P450 2C9 and 2C19 Substrates, S-Warfarin, Tolbutamide, Flurbiprofen, and Omeprazole.

Drug Metab. Dispos. 43 , 1408-16, (2015)

The common marmoset (Callithrix jacchus), a small New World monkey, has the potential for use in human drug development due to its evolutionary closeness to humans. Four novel cDNAs, encoding cytochro...

Investigation of two-dimensional high performance liquid chromatography approaches for reversed phase resolution of warfarin and hydroxywarfarin isomers.

J. Chromatogr. A. 1363 , 200-6, (2014)

Several offline and online 2D HPLC methods were investigated for the reversed phase resolution of a complex mixture of closely related warfarin and hydroxywarfarin isomers. By combining reversed phase...

Hydroxywarfarin metabolites potently inhibit CYP2C9 metabolism of S-warfarin.

Chem. Res. Toxicol. 23(5) , 939-45, (2010)

Coumadin (R/S-warfarin) anticoagulant therapy poses a risk to over 50 million Americans, in part due to interpersonal variation in drug metabolism. Consequently, it is important to understand how meta...

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