Leucomycin A5

Leucomycin A5用途

Leucomycin a5 is a metabolite from the leucomycin complex, which was originally isolated from S. kitasatoensis. It is active against a variety of Gram-positive and Gram-negative bacteria (MICs = 0.04-0.8 μg/ml) but not against K. pneumoniae, S. typhimurium, or E. coli with MICs ranging from 5 to >10 μg/ml. Leucomycin A5 is also active against penicillin-susceptible and -resistant S. pyogenes (MICs = 0.8 and 3.2 μg/ml, respectively) and S. faecalis (MIC = 0.8 μg/ml).

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Leucomycin A5名称

[ CAS 号 ]:
18361-45-0

[ 英文名 ]:
Leucomycin A5

[英文别名 ]:

leuco-indirubin
leucomycin A5

Leucomycin A5物理化学性质

[ 密度 ]:
1.22g/cm3

[ 沸点 ]:
871.4ºC at 760 mmHg

[ 分子式 ]:
C₃₉H₆₅NO₁₄

[ 分子量 ]:
771.93200

[ 闪点 ]:
480.8ºC

[ 精确质量 ]:
771.44100

[ PSA ]:
199.98000

[ LogP ]:
2.19660

[ 蒸汽压 ]:
1.86E-35mmHg at 25°C

[ 折射率 ]:
1.543

[ 储存条件 ]:
-20°C，密闭，干燥

Leucomycin A5毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: OH4726170

CHEMICAL NAME :: Leucomycin V, 4(sup B)-butanoate

CAS REGISTRY NUMBER :: 18361-45-0

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C39-H65-N-O14

MOLECULAR WEIGHT :: 772.05

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >1 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #3535309

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #3535309