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NQTrp

NQTrp用途

NQTrp,一种芳香萘醌色氨酸杂化分子,一种具有一般抗淀粉样变性作用的tau蛋白聚集抑制剂。NQTrp抑制六肽(γD-晶体蛋白N端的41GCWMLY46)以及全长γD-晶体蛋白的体外聚集[1]。

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NQTrp名称

[ CAS 号 ]:
185351-19-3

[ 中文名 ]:
NQTrp

[ 英文名 ]:
NQTrp

[英文别名 ]:

TRY001

NQTrp生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 神经疾病

[体外研究]

在TEM分析中,在NQTrp 5:1、1:1、1:5比例(GDC6:NQTrp)存在下,GDC6肽原纤维(50μM)。NQTrp以剂量依赖性方式有效抑制GDC6肽(50μM)的纤颤,并防止细长淀粉样纤维的形成[1]。NQTrp对视网膜细胞培养没有毒性作用,并降低ARPE-19细胞中六肽(IC50=70μM)聚集体诱导的细胞毒性[1]。

[参考文献]

[1]. Malak Abu-Hussien, et al. An amyloidogenic hexapeptide from the cataract-associated γD-crystallin is a model for the full-length protein and is inhibited by naphthoquinone-tryptophan hybrids. Int J Biol Macromol. 2020 Aug 15;157:424-433.

NQTrp物理化学性质

[ 分子式 ]:
C₂₁H₁₆N₂O₄

[ 分子量 ]:
360.36300

[ 精确质量 ]:
360.11100

[ PSA ]:
99.26000

[ LogP ]:
3.10720

[ 储存条件 ]:
-20°C，密闭，干燥

NQTrpMSDS

详细MSDS(安全技术说明书)

NQTrp安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302

[ 危险品运输编码 ]:
NONH for all modes of transport

NQTrp文献

Combined experimental and simulation studies suggest a revised mode of action of the anti-Alzheimer disease drug NQ-Trp.

Chemistry 21 , 12657-66, (2015)

Inhibition of the aggregation of the monomeric peptide β-amyloid (Aβ) into oligomers is a widely studied therapeutic approach in Alzheimer's disease (AD). Many small molecules have been reported to wo...

Naphthoquinone-Tryptophan Hybrid Inhibits Aggregation of the Tau-Derived Peptide PHF6 and Reduces Neurotoxicity.

J. Alzheimers Dis. 51 , 165-78, (2016)

Tauopathies, such as Alzheimer's disease (AD), are a group of disorders characterized neuropathologically by intracellular toxic accumulations of abnormal protein aggregates formed by misfolding of th...

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