棕榈酰辅酶A

棕榈酰辅酶A用途

棕榈酰辅酶A锂盐是与辅酶A共价连接的长链脂肪酸（C16）。棕榈酸酯与棕榈酰辅酶A锂盐的共价结合是多种细胞和病毒蛋白中的常见现象，起着重要作用促进膜结合。通过棕榈酰辅酶进行棕榈酰化锂盐也可能是延长或增强G蛋白信号传导的一般机制。棕榈酰辅酶A锂盐也已用于显微注射new卵，以研究柠檬酸合酶抑制在卵活化中的作用。棕榈酰辅酶A锂盐也称为辅酶A（锂盐），十六烷酰基辅酶A和正十六烷酰基辅酶A. Palmitoyl coenzyme A lithium salt is a long chain fatty acid (C16) that is covalently linked to Coenzyme A. The covalent attachment of palmitate to Palmitoyl coenzyme A lithium salt is a common occurrence in a wide variety of cellular and viral proteins, playing a role in promoting membrane binding. Palmitoylation through Palmitoyl coenzyme A lithium salt may also be a general mechanism for prolonging or potentiating G-protein signaling. Palmitoyl coenzyme A lithium salt has also been used for microinjecting newt eggs, to study the effect of citrate synthase inhibition in egg activation. Palmitoyl coenzyme A lithium salt is also known as Coenzyme A (lithium salt), Hexadecanoyl coenzyme A, and n-Hexadecanoyl Coenzyme A.

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棕榈酰辅酶A名称

[ CAS 号 ]:
188174-64-3

[ 中文名 ]:
棕榈酰辅酶A锂盐

[ 英文名 ]:
Palmitoyl coenzyme A lithium

[英文别名 ]:

Palmitoyl coenzyme A lithium salt
n-Hexadecanoyl Coenzyme A
Hexadecanoyl coenzyme A
MFCD01863103

棕榈酰辅酶A生物活性

[ 描述 ]:

棕榈酰辅酶A锂是一种酰基辅酶A硫酯,可以通过肉碱穿梭系统运输到线粒体基质,并参与β-氧化。棕榈酰辅酶A锂也可用作鞘氨醇生物合成的底物[1][2]。

[ 相关类别 ]:

研究领域 >> 代谢疾病

[体外研究]

棕榈酰辅酶A锂(100μM)可逆抑制鸡肝细胞的乙酰辅酶A羧化酶活性,并与柠檬酸竞争,在体内脂肪酸合成的调节中具有重要作用[1]。线粒体中含量较高的棕榈酰辅酶A锂可减少ADP的进入,从而导致棕榈酰辅酸A对谷氨酸脱氢酶的抑制作用增强[2]。

[参考文献]

[1]. A G Goodridge, et al. Regulation of the activity of acetyl coenzyme A carboxylase by palmitoyl coenzyme A and citrate. J Biol Chem. 1972 Nov 10;247(21):6946-52.

[2]. L A Fahien, et al. Regulation of glutamate dehydrogenase by palmitoyl-coenzyme A. Arch Biochem Biophys. 1981 Nov;212(1):247-53.

棕榈酰辅酶A物理化学性质

[ 分子式 ]:
C₃₇H₆₅LiN₇O₁₇P₃S

[ 分子量 ]:
1011.876

[ 精确质量 ]:
1011.353027

[ 外观性状 ]:
固体

[ 储存条件 ]:
-20°C储存

[ 水溶解性 ]:
Soluble in water

棕榈酰辅酶A安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

棕榈酰辅酶A文献

Fatty acylation of proteins: new insights into membrane targeting of myristoylated and palmitoylated proteins.

Biochim. Biophys. Acta 1451 , 1, (1999)

Covalent attachment of myristate and/or palmitate occurs on a wide variety of viral and cellular proteins. This review will highlight the latest advances in our understanding of the enzymology of N-my...

Inhibition of brain Gz GAP and other RGS proteins by palmitoylation of G protein alpha subunits.

Science 278 , 1132-1135, (1997)

Palmitoylation of the alpha subunit of the guanine nucleotide-binding protein Gz inhibited by more than 90 percent its response to the guanosine triphosphatase (GTPase)-accelerating activity of Gz GAP...

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