AC-GLN-LYS-LEU-VAL-PHE-PHE-NH2

AC-GLN-LYS-LEU-VAL-PHE-PHE-NH2用途

Acetly-β Amyloid (15-20), Amide 是多肽片段。Acetly-β Amyloid (15-20), Amide 抑制 Aβ (1–40) 肽的β-折叠的形成并稳定其结构。Acetly-β Amyloid (15-20), Amide 可用于阿尔茨海默病的研究。

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AC-GLN-LYS-LEU-VAL-PHE-PHE-NH2名称

[ CAS 号 ]:
189064-06-0

[ 中文名 ]:
AC-GLN-LYS-LEU-VAL-PHE-PHE-NH2

[ 英文名 ]:
Acetyl-Amyloid β-Protein (15-20) amide trifluoroacetate salt

[英文别名 ]:

Ac-QKLVFF-NH2,amyloid blocker
Ac-QKLVFF-NH2
amyloid blocker
Acetyl-Amyloid |A-Protein Fragment 15-20 Amide
Ac-QKLVFF

AC-GLN-LYS-LEU-VAL-PHE-PHE-NH2生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 神经疾病

[参考文献]

[1]. Lin SY, et al. Fourier transform infrared spectroscopy used to evidence the prevention of beta-sheet formation of amyloid beta(1-40) peptide by a short amyloid fragment. Int J Biol Macromol. 2003 Sep;32(3-5):173-7.

AC-GLN-LYS-LEU-VAL-PHE-PHE-NH2物理化学性质

[ 分子式 ]:
C₄₂H₆₂N₈O₉

[ 分子量 ]:
822.99000

[ 精确质量 ]:
822.46400

[ PSA ]:
281.01000

[ LogP ]:
4.32770

AC-GLN-LYS-LEU-VAL-PHE-PHE-NH2MSDS

详细MSDS(安全技术说明书)

AC-GLN-LYS-LEU-VAL-PHE-PHE-NH2安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

AC-GLN-LYS-LEU-VAL-PHE-PHE-NH2文献

Arrest of beta-amyloid fibril formation by a pentapeptide ligand.

J. Biol. Chem. 271 , 8545-8548, (1996)

Polymerization of amyloid beta-peptide (Abeta) into amyloid fibrils is a critical step in the pathogenesis of Alzheimer's disease. Here, we show that peptides incorporating a short Abeta fragment (KLV...

Controlling amyloid beta-peptide fibril formation with protease-stable ligands.

J. Biol. Chem. 272 , 12601-12605, (1997)

We have previously shown that short peptides incorporating the sequence KLVFF can bind to the approximately 40amino acid residue Alzheimer amyloid beta-peptide (Abeta) and disrupt amyloid fibril forma...

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