L-Glutamic acid,N-[4-[[(2,4-diamino-6-quinazolinyl)methyl]amino]benzoyl]-

名称

[ CAS 号 ]:
18921-68-1

[ 英文名 ]:
L-Glutamic acid,N-[4-[[(2,4-diamino-6-quinazolinyl)methyl]amino]benzoyl]-

[英文别名 ]:

Deazaminopterin
Deaza-Aminopterin
Dideaza-aminopterin
CB-3702
5,8-Dideazaaminopterin

物理化学性质

[ 密度 ]:
1.508g/cm3

[ 分子式 ]:
C₂₁H₂₂N₆O₅

[ 分子量 ]:
438.43700

[ 精确质量 ]:
438.16500

[ PSA ]:
193.55000

[ LogP ]:
3.08040

[ 折射率 ]:
1.747

毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MA1247500

CHEMICAL NAME :: Glutamic acid, N-(p-(((2,4-diamino-6-quinazolinyl)methyl)amino)benzo yl)-, L-

CAS REGISTRY NUMBER :: 18921-68-1

LAST UPDATED :: 198312

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C21-H22-N6-O5

MOLECULAR WEIGHT :: 438.49

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 65 mg/kg

TOXIC EFFECTS :: Tumorigenic - active as anti-cancer agent

REFERENCE :: GWXXBX German Offenlegungsschrift Patent Document. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #2709506

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 65 mg/kg

TOXIC EFFECTS :: Tumorigenic - active as anti-cancer agent

REFERENCE :: GWXXBX German Offenlegungsschrift Patent Document. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #2709506

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安全信息

[ 海关编码 ]:
2933990090

海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%