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琥珀酸-13C4

琥珀酸-13C4用途

琥珀酸-13C4是13C标记的琥珀酸[1]。琥珀酸是一种强效口服抗焦虑剂。琥珀酸是三羧酸循环的中间产物。琥珀酸可作为食品、化学和制药行业中许多重要工业化学品的前体[2][3]。

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琥珀酸-13C4名称

[ CAS 号 ]:
201595-67-7

[ 中文名 ]:
琥珀酸-13C4

[ 英文名 ]:
Succinic acid-13C4

[中文别名 ]:

丁二酸-13C4

[英文别名 ]:

Yantar-antitox-13C4
Dihydrofumaric Acid-13C4
Amber Acid-13C4
1,4-Butanedioic Acid-13C4
MFCD00145335
Butanedioic acid-13C4
Katasuccin-13C4
Wormwood Acid-13C4
Asuccin-13C4

琥珀酸-13C4生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 神经疾病

[体外研究]

氢、碳和其他元素的稳定重同位素已被掺入药物分子中,主要作为药物开发过程中定量的示踪剂。头韵因其可能影响药物的药代动力学和代谢特征而受到关注[1]。

[参考文献]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.

[2]. Zhang YJ, et al. Optimization of succinic acid fermentation with Actinobacillus succinogenes by response surface methodology (RSM). J Zhejiang Univ Sci B. 2012 Feb;13(2):103-10.

[3]. A T JOHNS, et al. The production of propionic acid by decarboxylation of succinic acid in a bacterial fermentation. Biochem J. 194842(1):ii.

[4]. Si Wei Chen, Anxiolytic-like effect of succinic acid in mice. Life Sci. 2003 Nov 773(25):3257-64.

琥珀酸-13C4物理化学性质

[ 密度 ]:
1.408g/cm3

[ 沸点 ]:
235ºC

[ 熔点 ]:
187-190ºC(lit.)

[ 分子式 ]:
C₄H₆O₄

[ 分子量 ]:
122.05900

[ 精确质量 ]:
122.04000

[ PSA ]:
74.60000

[ 折射率 ]:
1.477

琥珀酸-13C4安全信息

[ 符号 ]:

GHS05, GHS07

[ 信号词 ]:
Danger

[ 危害声明 ]:
H315-H318-H335

[ 警示性声明 ]:
P261-P280-P305 + P351 + P338

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
26-36

[ 危险品运输编码 ]:
NONH for all modes of transport

琥珀酸-13C4文献

Metabolomics study of hepatocellular carcinoma: discovery and validation of serum potential biomarkers by using capillary electrophoresis-mass spectrometry.

J. Proteome Res. 13(7) , 3420-31, (2014)

Hepatocellular carcinoma (HCC) is one of the most lethal malignancies. The lack of effective screening methods for early diagnosis has been a longstanding bottleneck to improve the survival rate. In t...

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