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地喹碘铵

地喹碘铵名称

[ CAS 号 ]:
2019-42-3

[ 中文名 ]:
地喹碘铵

[ 英文名 ]:
DEQUALINIUM IODIDE

[英文别名 ]:

Dequalinium iodide
Dequalinium Diiodide
1,1'-Decamethylenebis(4-aminoquinaldinium iodide)
EINECS 217-964-5
MFCD00191973

地喹碘铵物理化学性质

[ 熔点 ]:
>300ºC (dec.)(lit.)

[ 分子式 ]:
C₃₀H₄₀I₂N₄

[ 分子量 ]:
710.47400

[ 精确质量 ]:
710.13400

[ PSA ]:
59.80000

[ LogP ]:
1.34060

地喹碘铵毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: VA0705000

CHEMICAL NAME :: Quinaldinium, 1,1'-decamethylenebis(4-amino-, diiodide

CAS REGISTRY NUMBER :: 2019-42-3

LAST UPDATED :: 199603

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C30-H40-N4.2I

MOLECULAR WEIGHT :: 710.54

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 21 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPPMAB Journal of Pharmacy and Pharmacology. (Pharmaceutical Soc. of Great Britain, 1 Lambeth High St., London SEI 7JN, UK) V.1- 1949- Volume(issue)/page/year: 8,110,1956

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地喹碘铵安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi: Irritant;

[ 风险声明 (欧洲) ]:
36/37/38

[ 安全声明 (欧洲) ]:
26-36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ RTECS号 ]:
VA0705000

地喹碘铵文献

Antimicrobial topical agents used in the vagina.

Curr. Probl. Dermatol. 40 , 36-47, (2011)

Vaginally applied antimicrobial agents are widely used in the vagina in women with lower genital tract infections. An 'antimicrobial' is a general term that refers to a group of drugs that are effecti...

Dequalinium induces cytotoxicity in human leukemia NB4 cells by downregulation of Raf/MEK/ERK and PI3K/Akt signaling pathways and potentiation of specific inhibitors of these pathways.

Leuk. Res. 38(7) , 795-803, (2014)

Delocalized lipophilic cation dequalinium (DQA) selectively accumulates in mitochondria and displays anticancer activity in different malignancies. Our previous studies indicate a DQA-induced cytotoxi...

N-palmitoyl-ethanolamine (PEA) induces peripheral antinociceptive effect by ATP-sensitive K+-channel activation.

J. Pharmacol. Sci. 118(2) , 156-60, (2012)

Although the antinociceptive effects of N-palmitoyl-ethanolamine (PEA) were first characterized nearly 50 years ago, the identity of the mechanism that mediates these actions has not been elucidated. ...

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