Card-20(22)-enolide,3-[(2-O-b-D-glucopyranosyl-b-D-glucopyranosyl)oxy]-14-hydroxy-,(3b,5a)- (9CI)

用途

Uzarin 是一种甾体苷。Uzarin 没有抑制细胞增殖或诱导细胞凋亡的作用。

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名称

[ CAS 号 ]:
20231-81-6

[ 英文名 ]:
Card-20(22)-enolide,3-[(2-O-b-D-glucopyranosyl-b-D-glucopyranosyl)oxy]-14-hydroxy-,(3b,5a)- (9CI)

[英文别名 ]:

uzarigenin+2-d-glucose
anosyl)oxy)-14-hydroxy

生物活性

[ 描述 ]:

Uzarin 是一种甾体苷。Uzarin 没有抑制细胞增殖或诱导细胞凋亡的作用。

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[参考文献]

[1]. Delebinski CI, et al. Analysis of proliferation and apoptotic induction by 20 steroid glycosides in 143B osteosarcoma cells in vitro. Cell Prolif. 2015 Oct;48(5):600-10.

物理化学性质

[ 密度 ]:
1.46g/cm3

[ 沸点 ]:
904.4ºC at 760mmHg

[ 分子式 ]:
C₃₅H₅₄O₁₄

[ 分子量 ]:
698.79

[ 闪点 ]:
281ºC

[ 精确质量 ]:
698.35100

[ PSA ]:
225.06000

[ 蒸汽压 ]:
0mmHg at 25°C

[ 折射率 ]:
1.635

毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: FH5093000

CHEMICAL NAME :: 5-alpha-Card-20(22)-enolide, 3-beta-((6-O-beta-D-glucopyranosyl-beta-D-glucopyrano syl)oxy)- 14-hydroxy-

CAS REGISTRY NUMBER :: 20231-81-6

LAST UPDATED :: 199209

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C35-H54-O14

MOLECULAR WEIGHT :: 698.89

WISWESSER LINE NOTATION :: L E5 B666TJ A1 E1 IQ F- DT5OV EHJ& OO- BT6OTJ CQ DQ EQ F1O- BT6OTJ CQ DQ EQ F1Q

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 4590 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85ELDJ "Die Herzwirksamen Glykoside," Baumgarten, G., and W. Forster, Leipzig, Ger. Dem. Rep., VEB Georg Thieme, 1963 Volume(issue)/page/year: -,194,1963