甲醇:水(1:1)测试标样(吗啡-6-Β-D-葡糖苷酸)

名称

[ CAS 号 ]:
20290-10-2

[ 中文名 ]:
甲醇:水(1:1)测试标样(吗啡-6-Β-D-葡糖苷酸)

[ 英文名 ]:
M-6-G TRIFLUOROACETATE-HYDRATE

[英文别名 ]:

Morphine glucuronide

物理化学性质

[ 密度 ]:
1.64g/cm3

[ 沸点 ]:
731.6ºC at 760mmHg

[ 熔点 ]:
237-240°C (dec.)

[ 分子式 ]:
C₂₃H₂₇NO₉

[ 分子量 ]:
461.46200

[ 闪点 ]:
396.3ºC

[ 精确质量 ]:
461.16900

[ PSA ]:
149.15000

[ 蒸汽压 ]:
1.8E-22mmHg at 25°C

[ 折射率 ]:
1.731

[ 储存条件 ]:
−20°C

MSDS

详细MSDS(安全技术说明书)

毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LZ6500700

CHEMICAL NAME :: Glucopyranosiduronic acid, 7,8-didehydro-4,5-alpha-epoxy-3-hydroxy-17-methylmorp hinan-6- alpha-yl-, beta-D-

CAS REGISTRY NUMBER :: 20290-10-2

LAST UPDATED :: 198909

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C23-H27-N-O9

MOLECULAR WEIGHT :: 461.51

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 432 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 67(4),97P,1971

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安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H312-H317-H332

[ 警示性声明 ]:
P280

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ 危害码 (欧洲) ]:
Xn: Harmful;

[ 风险声明 (欧洲) ]:
20/21/22-43

[ 安全声明 (欧洲) ]:
36

[ 危险品运输编码 ]:
UN 1993C 3 / PGIII

[ WGK德国 ]:
3

[ RTECS号 ]:
LZ6500700

文献

Morphine glucuronidation increases its analgesic effect in guinea pigs.

Life Sci. 109(2) , 104-10, (2014)

Morphine is extensively metabolized to neurotoxic morphine-3-glucuronide (M3G) and opioid agonist morphine-6-glucuronide (M6G). Due to these different roles, interindividual variability and co-adminis...

[Rapid opiate detoxification under anesthesia (RODA)].

Rev. Med. Liege. 68(5-6) , 298-302, (2013)

Rapid Opiate Detoxification under Anesthesia (RODA) involves the use of opiate antagonists combined with anesthesia and pharmacotherapy to reduce withdrawal symptoms. The aim of our study was to measu...

[Blood-brain barrier transport of opioid analgesics].

Yakugaku Zasshi 131(10) , 1445-51, (2011)

Opioid analgesics exhibit cationic properties under physiological conditions, and the mechanism underlying permeation of the blood-brain barrier thus cannot be fully explained by simple diffusion alon...

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