3,5,5,7-tetramethyl-6H-[1,3]thiazolo[3,2-a]pyrimidin-7-ol,hydrochloride

名称

[ CAS 号 ]:
21457-22-7

[ 英文名 ]:
3,5,5,7-tetramethyl-6H-[1,3]thiazolo[3,2-a]pyrimidin-7-ol,hydrochloride

物理化学性质

[ 沸点 ]:
313.9ºC at 760 mmHg

[ 分子式 ]:
C₁₀H₁₇ClN₂OS

[ 分子量 ]:
248.77300

[ 闪点 ]:
143.7ºC

[ 精确质量 ]:
248.07500

[ PSA ]:
65.76000

[ LogP ]:
1.84360

[ 蒸汽压 ]:
4.17E-05mmHg at 25°C

毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XJ7055400

CHEMICAL NAME :: 5H-Thiazolo(3,2-a)pyrimidin-7-ol, 6,7-dihydro-3,5,5,7-tetramethyl-, monohydrochloride

CAS REGISTRY NUMBER :: 21457-22-7

LAST UPDATED :: 198406

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C10-H16-N2-O-S.Cl-H

MOLECULAR WEIGHT :: 248.80

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 820 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - tremor Behavioral - convulsions or effect on seizure threshold

REFERENCE :: PHARAT Pharmazie. (VEB Verlag Volk und Gesundheit, Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.) V.1- 1946- Volume(issue)/page/year: 24,572,1969

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 360 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - tremor Behavioral - convulsions or effect on seizure threshold

REFERENCE :: PHARAT Pharmazie. (VEB Verlag Volk und Gesundheit, Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.) V.1- 1946- Volume(issue)/page/year: 24,572,1969

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 795 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PHARAT Pharmazie. (VEB Verlag Volk und Gesundheit, Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.) V.1- 1946- Volume(issue)/page/year: 24,572,1969

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