4-Piperidinamine, 1-[3-(2,3-dichlorophenyl)-1H-pyrazolo[3,4-b]pyrazin-6-yl]-4-methyl-

IACS-13909 is a specific and potent allosteric inhibitor of SHP2 that suppresses the signaling of RTK/MAPK pathway and overcomes multiple mechanisms underlying osimertinib resistance. IACS-13909 potently impedes the proliferation of tumors with a broad spectrum of RTKs as the oncogenic driver. Importantly, in NSCLC models with acquired resistance to osimertinib, IACS-13909 administered as a single agent or in combination with osimertinib potently reduces tumor cell proliferation in vitro and in vivo. Together, our findings provide preclinical evidence for using a SHP2 inhibitor as a therapeutic strategy in acquired EGFR inhibitor-resistant NSCLC.

[ 分子式 ]:
C₁₇H₁₈Cl₂N₆

[ 分子量 ]:
377.27

[ 储存条件 ]:
-20°C

公司名：上海化源世纪贸易有限公司

区域：上海市普陀区

价格：

联系人：徐经理

产品详情：IACS-13909

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公司名：上海源溪生物科技有限公司

区域：上海市浦东新区

价格：
￥需询单/1g

联系人：赖经理

产品详情：IACS-13909

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公司名：上海脉铂医药科技有限公司

区域：上海市嘉定区

价格：
￥11667.0/25mg

联系人：李先生

产品详情：IACS-13909

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公司名：上海阿拉丁生化科技股份有限公司

区域：上海市浦东新区

价格：
￥3294.9/10mg ￥1029.9/1mg ￥2059.9/5mg ￥6179.9/25mg

联系人：阿拉丁

产品详情：IACS-13909

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公司名：武汉壹加壹生物科技有限公司

区域：武汉市江夏区

价格：
￥需询单/1mg

联系人：刘经理

产品详情：IACS-13909

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4-Piperidinamine, 1-[3-(2,3-dichlorophenyl)-1H-pyrazolo[3,4-b]pyrazin-6-yl]-4-methyl-供应商