ELARGIN
ELARGIN名称
[ CAS 号 ]:
2169-75-7
[ 英文名 ]:
ELARGIN
[英文别名 ]:
- Elargyl
- Elargin
- SU-Brontine
- Brontine
- Brontisol
- Dibenzheptropine citrate salt
- Brontina
- Brontin (Porontine)
- Brontin
- Deptropine citrate
ELARGIN物理化学性质
[ 密度 ]:
1.15g/cm3
[ 沸点 ]:
446.3ºC at 760mmHg
[ 分子式 ]:
C29H35NO8
[ 分子量 ]:
525.59000
[ 闪点 ]:
130.4ºC
[ 精确质量 ]:
525.23600
[ PSA ]:
144.60000
[ LogP ]:
3.20580
ELARGIN毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- YM3065000
- CAS REGISTRY NUMBER :
- 2169-75-7
- LAST UPDATED :
- 199509
- DATA ITEMS CITED :
- 6
- MOLECULAR FORMULA :
- C23-H27-N-O.C6-H8-O7
- MOLECULAR WEIGHT :
- 525.65
- WISWESSER LINE NOTATION :
- L C676&T&J BO- GT56 A ANTJ A1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 445 mg/kg
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation)
- REFERENCE :
- AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 148,135,1964
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 300 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 23,854,1973
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 66 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 23,854,1973
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 32 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- APPNAH Acta Physiologica et Pharmacologica Neerlandica. (Amsterdam, Netherlands) V.1-15, 1950-69. For publisher information, see EJPHAZ. Volume(issue)/page/year: 11,104,1962
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 75 mg/kg
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation) Behavioral - ataxia
- REFERENCE :
- AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 148,135,1964 ** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 2352 mg/kg/8W-I
- TOXIC EFFECTS :
- Related to Chronic Data - death
- REFERENCE :
- APPNAH Acta Physiologica et Pharmacologica Neerlandica. (Amsterdam, Netherlands) V.1-15, 1950-69. For publisher information, see EJPHAZ. Volume(issue)/page/year: 11,104,1962
ELARGIN文献
Br. J. Dis. Chest 58 , 135-40, (1964)
Uptake of quaternary ammonium compounds into rat intestinal brush border membrane vesicles.
Biochem. Pharmacol. 30(19) , 2637-41, (1981)
[Alarming increase in poisonings due to deptoprine].
Ned. Tijdschr. Geneeskd. 140(13) , 729, (1996)
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相关化合物
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