L-Glutamic acid,N-[4-[[1-(2-amino-3,4-dihydro-4-oxo-6-pteridinyl)ethyl]amino]benzoyl]-

用途

Ninopterin (9-Me-PGA; 9-Methyl PGA) 是一种叶酸类似物。
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名称

[ CAS 号 ]:
2179-16-0

[ 英文名 ]:
L-Glutamic acid,N-[4-[[1-(2-amino-3,4-dihydro-4-oxo-6-pteridinyl)ethyl]amino]benzoyl]-

[英文别名 ]:

生物活性

[ 描述 ]:

Ninopterin (9-Me-PGA; 9-Methyl PGA) 是一种叶酸类似物。

[ 相关类别 ]:

研究领域 >> 其他
信号通路 >> 其他 >> 其他

[参考文献]

[1]. K P Chepenik, Effects of transitory maternal pteroylglutamic acid (PGA) deficiency on respiratory control ratios, phosphorylative capacity, and cytochrome oxidase activities of mitochondria from rat embryos. Teratology (Report missing IFs). 1972 Apr;5(2):191-8.  

物理化学性质

[ 密度 ]:
1.64g/cm3

[ 分子式 ]:
C20H21N7O6

[ 分子量 ]:
455.42400

[ 精确质量 ]:
455.15500

[ PSA ]:
213.54000

[ LogP ]:
1.97360

[ 折射率 ]:
1.746

[ 储存条件 ]:
库房通风低温干燥

毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :
MA0602000
CHEMICAL NAME :
Glutamic acid, N-(p-((1-(2-amino-4-hydroxy-6-pteridinyl)ethyl)amino) benzoyl)- L-
CAS REGISTRY NUMBER :
2179-16-0
BEILSTEIN REFERENCE NO. :
0069787
LAST UPDATED :
199612
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C20-H21-N7-O6
MOLECULAR WEIGHT :
455.48
WISWESSER LINE NOTATION :
T6MTJ BZ DQ F2MR DVMYVQ2VQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
20 mg/kg
SEX/DURATION :
female 10-12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Specific Developmental Abnormalities - other developmental abnormalities
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 1,375,1968
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
405 mg/kg
SEX/DURATION :
female 11-14 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - other effects to embryo
REFERENCE :
BNEOBV Biology of the Neonate. (S. Karger Pub., Inc., 79 Fifth Ave., New York, NY 10003) V.15- 1970- Volume(issue)/page/year: 41,52,1982
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
400 mg/kg
SEX/DURATION :
female 11-14 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
JEEMAF Journal of Embryology and Experimental Morphology. (Essex, UK) V.1-98, 1953-86. For Publisher information, see DEVPED Volume(issue)/page/year: 41,289,1977
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相关化合物

CAS号[2179-16-0]化源网提供[L-Glutamic acid,N-[4-[[1-(2-amino-3,4-dihydro-4-oxo-6-pteridinyl)ethyl]amino]benzoyl]-]MSDS、说明、性质、英文名、生产厂家、作用/用途、分子量、密度、沸点、熔点、结构式等。>>电脑版：L-Glutamic acid,N-[4-[[1-(2-amino-3,4-dihydro-4-oxo-6-pteridinyl)ethyl]amino]benzoyl]-

标题：【L-Glutamic acid,N-[4-[[1-(2-amino-3,4-dihydro-4-oxo-6-pteridinyl)ethyl]amino]benzoyl]-】L-Glutamic acid,N-[4-[[1-(2-amino-3,4-dihydro-4-oxo-6-pteridinyl)ethyl]amino]benzoyl]- CAS号:2179-16-0【结构式 性质 活性】-化源网 地址：https://m.chemsrc.com/mip/cas/2179-16-0_169608.html