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MPEP盐酸盐

MPEP盐酸盐用途

MPEP盐酸盐是非竞争性mGlu5受体拮抗剂,IC50为36 nM。

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MPEP盐酸盐名称

[ CAS 号 ]:
219911-35-0

[ 中文名 ]:
2-甲基-6-苯基乙炔基吡啶盐酸盐

[ 英文名 ]:
MPEP (Hydrochloride)

[英文别名 ]:

6-Methyl-2-(phenylethynyl)pyridine hydrochloride
2-Methyl-6-(phenylethynyl)pyridine hydrochloride
Pyridine,6-methyl-2-(phenylethynyl)
MPEP (Hydrochloride)
6-methyl-2-(phenylethynyl)pyridine
MPEP HYDROCHLORIDE

MPEP盐酸盐生物活性

[ 描述 ]:

MPEP盐酸盐是非竞争性mGlu5受体拮抗剂,IC50为36 nM。

[ 相关类别 ]:

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 谷氨酸受体

研究领域 >> 神经疾病

[参考文献]

[1]. Inta, Dragos; Filipovic, Dragana; Lima-Ojeda, Juan M. et al. The mGlu5 receptor antagonist MPEP activates specific stress-related brain regions and lacks neurotoxic effects of the NMDA receptor antagonist MK-801: Significance for the use as anxiolytic/ant

[2]. Chau, Peipei; Soederpalm, Bo; Ericson, Mia The mGluR5 antagonist MPEP elevates accumbal dopamine and glycine levels; interaction with strychnine-sensitive glycine receptors. Addiction Biology (2011), 16(4), 591-599.

[3]. D'Souza, Manoranjan S.; Markou, Athina Metabotropic glutamate receptor 5 antagonist 2-methyl-6-(phenylethynyl)pyridine (MPEP) microinfusions into the nucleus accumbens shell or ventral tegmental area attenuate the reinforcing effects of nicotine in rats.

[相关活性小分子]

Mavoglurant | L-谷氨酰胺 | CTEP | (1S,2S,5R,6S)-2-氨基二环[3.1.0]己烷-2,6-二羧酸 | 谷氨酸钠 | ADX88178 | FITM | (S)-MCPG | Basimglurant | (2S)-2-氨基-2-[(1S,2S)-2-羧基环丙-1-基]-3-(吨-9-基)丙酸 | 6-氟-2-[4-(吡啶-2-基)-3-丁炔基]咪唑并[1,2-A]吡啶 | JNJ-40411813 | (1R,4S,5S,6S)-4-氨基-2-硫杂双环[3.1.0]己烷-4,6-二甲酸 2,2-二氧化物 | JNJ16259685 | (S)-(4-氟苯基)-{3-[3-(4-氟苯基)-[1,2,4]二唑-5-基]哌啶-1-基}甲酮

MPEP盐酸盐物理化学性质

[ 密度 ]:
1.1g/cm3

[ 沸点 ]:
336.3ºC at 760mmHg

[ 分子式 ]:
C₁₄H₁₂ClN

[ 分子量 ]:
229.705

[ 闪点 ]:
144.8ºC

[ 精确质量 ]:
229.065826

[ PSA ]:
12.89000

[ LogP ]:
3.59180

[ 外观性状 ]:
light yellow solid

[ 蒸汽压 ]:
0.000221mmHg at 25°C

[ 折射率 ]:
1.614

[ 储存条件 ]:
-20℃

MPEP盐酸盐MSDS

详细MSDS(安全技术说明书)

MPEP盐酸盐安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ 海关编码 ]:
2933399090

MPEP盐酸盐海关

[ 海关编码 ]: 2933399090

[ 中文概述 ]:
2933399090. 其他结构含非稠合吡啶环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

MPEP盐酸盐文献

Group I metabotropic glutamate receptor-mediated activation of PKC gamma in the nucleus accumbens core promotes the reinstatement of cocaine seeking.

Addict. Biol. 20(2) , 285-96, (2015)

Emerging evidence indicates that type I metabotropic glutamate receptors (mGluRs) in the nucleus accumbens play a critical role in cocaine seeking. The present study sought to determine the role of ac...

Endocannabinoids mediate bidirectional striatal spike-timing-dependent plasticity.

J. Physiol. 593 , 2833-49, (2015)

Although learning can arise from few or even a single trial, synaptic plasticity is commonly assessed under prolonged activation. Here, we explored the existence of rapid responsiveness of synaptic pl...

Estradiol mediates dendritic spine plasticity in the nucleus accumbens core through activation of mGluR5.

Brain Struct. Funct. 220 , 2415-22, (2015)

Accumulating evidence from human and rodent studies suggests that females are more sensitive to the motivating and rewarding properties of drugs of abuse. Numerous reports implicate estradiol in enhan...

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