4-羧基甲苯磺丁脲

[ 密度 ]:
1.337g/cm3

[ 熔点 ]:
210-212ºC

[ 分子式 ]:
C₁₂H₁₆N₂O₅S

[ 分子量 ]:
300.33100

[ 精确质量 ]:
300.07800

[ PSA ]:
120.95000

[ LogP ]:
3.03540

[ 折射率 ]:
1.558

[ 储存条件 ]:
室温

详细MSDS(安全技术说明书)

[ 符号 ]:

GHS05

[ 信号词 ]:
Danger

[ 危害声明 ]:
H318

[ 警示性声明 ]:
P280-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi: Irritant;

[ 风险声明 (欧洲) ]:
41

[ 安全声明 (欧洲) ]:
26-39

[ 危险品运输编码 ]:
NONH for all modes of transport

[ 海关编码 ]:
2935009090

详细合成路线

[ 海关编码 ]: 2935009090

[ 中文概述 ]:
2935009090 其他磺（酰）胺. 增值税率:17.0% 退税率:9.0% 监管条件:无 最惠国关税:6.5% 普通关税:35.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%

Liquid chromatography/tandem mass spectrometry method for simultaneous evaluation of activities of five cytochrome P450s using a five-drug cocktail and application to cytochrome P450 phenotyping studies in rats.

J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 871(1) , 78-89, (2008)

A reliable liquid chromatography/tandem mass spectrometry has been developed for simultaneous evaluation of the activities of five cytochrome P450s (CYP1A2, CYP2C9, CYP2C19, CYP2D6, and CYP3A) in rat ...

Cytochrome P450 2C9 phenotyping using low-dose tolbutamide.

Eur. J. Clin. Pharmacol. 60(3) , 165-71, (2004)

The hypoglycaemic drug tolbutamide is used for assessment of CYP2C9 activity in vivo. However, therapeutically active doses of 500 mg bear the risk of hypoglycaemia, and a tolbutamide-derived paramete...

Quantitative determination of tolbutamide and its metabolites in human plasma and urine by high-performance liquid chromatography and UV detection.

Ther. Drug Monit. 21(6) , 664-71, (1999)

An isocratic, high-performance liquid chromatography method has been developed for simultaneous determination of the oral antidiabetic tolbutamide and two of its metabolites, 4-hydroxytolbutamide and ...

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