普罗喹宗
普罗喹宗名称
[ CAS 号 ]:
22760-18-5
[ 中文名 ]:
普罗喹宗
[ 英文名 ]:
proquazone
[英文别名 ]:
- EINECS 245-203-7
- Sandoz 43-715
- 7-methyl-1-isopropyl-4-phenyl-quinazolin-2(1H)-one
- Proquazonum [INN-Latin]
- 1-Isopropyl-4-phenyl-7-methyl-2(1H)-quinazolinone
- 7-methyl-1-isopropyl-4-phenyl-2(1H)-quinazolinone
- Biarison
- 1-isopropyl-7-methyl-4-phenyl-quinazolin-2(1H)-one
- PROQUAZONE
- 1-isopropyl-7-methyl-4-phenyl-1H-quinazolin-2-one
普罗喹宗物理化学性质
[ 密度 ]:
1.12g/cm3
[ 沸点 ]:
440.6ºC at 760mmHg
[ 熔点 ]:
137-138 °C
[ 分子式 ]:
C18H18N2O
[ 分子量 ]:
278.34800
[ 闪点 ]:
220.3ºC
[ 精确质量 ]:
278.14200
[ PSA ]:
34.89000
[ LogP ]:
3.95280
[ 蒸汽压 ]:
5.79E-08mmHg at 25°C
[ 折射率 ]:
1.605
[ 储存条件 ]:
2-8°C
普罗喹宗毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- VA3530000
- CHEMICAL NAME :
- 2(1H)-Quinazolinone, 1-isopropyl-7-methyl-4-phenyl-
- CAS REGISTRY NUMBER :
- 22760-18-5
- BEILSTEIN REFERENCE NO. :
- 0889725
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 8
- MOLECULAR FORMULA :
- C18-H18-N2-O
- MOLECULAR WEIGHT :
- 278.38
- WISWESSER LINE NOTATION :
- T66 BNVNJ BY1&1 ER& I1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 759 mg/kg
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - ptosis Behavioral - altered sleep time (including change in righting reflex) Behavioral - somnolence (general depressed activity)
- REFERENCE :
- DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78- Volume(issue)/page/year: 3,361,1980
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 375 mg/kg
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - ptosis Behavioral - altered sleep time (including change in righting reflex) Behavioral - antipsychotic
- REFERENCE :
- DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78- Volume(issue)/page/year: 3,361,1980
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 930 mg/kg
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - ptosis Behavioral - altered sleep time (including change in righting reflex) Behavioral - somnolence (general depressed activity)
- REFERENCE :
- DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78- Volume(issue)/page/year: 3,361,1980
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 339 mg/kg
- TOXIC EFFECTS :
- Behavioral - general anesthetic Behavioral - somnolence (general depressed activity) Behavioral - changes in motor activity (specific assay)
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 34,879,1984
- TYPE OF TEST :
- LD - Lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- >800 mg/kg
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - ptosis Behavioral - altered sleep time (including change in righting reflex) Behavioral - somnolence (general depressed activity)
- REFERENCE :
- DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78- Volume(issue)/page/year: 3,361,1980
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 260 mg/kg
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - ptosis Behavioral - altered sleep time (including change in righting reflex) Behavioral - antipsychotic
- REFERENCE :
- DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78- Volume(issue)/page/year: 3,361,1980 ** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 9100 mg/kg/13W-C
- TOXIC EFFECTS :
- Gastrointestinal - other changes Related to Chronic Data - death
- REFERENCE :
- DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78- Volume(issue)/page/year: 3,361,1980
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - pig
- DOSE/DURATION :
- 6916 mg/kg/26W-C
- TOXIC EFFECTS :
- Gastrointestinal - ulceration or bleeding from stomach Blood - changes in erythrocyte (RBC) count Related to Chronic Data - death
- REFERENCE :
- DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78- Volume(issue)/page/year: 3,361,1980
普罗喹宗安全信息
[ 海关编码 ]:
2933990090
普罗喹宗合成路线
普罗喹宗上下游产品
普罗喹宗上游产品
普罗喹宗下游产品
普罗喹宗海关
[ 海关编码 ]: 2933990090
[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
推荐生产厂家/供应商：
公司名：上海化源世纪贸易有限公司
区域：上海市普陀区
价格：
联系人：徐经理
产品详情：普罗喹宗
公司名：上海创赛科技有限公司
区域：上海市嘉定区
价格：
￥2265.0/5mg
￥764.0/1mg
联系人：夏言
产品详情：[Perfemiker]普罗喹宗,95%
查看所有供应商请点击：
相关化合物
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