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盐酸甲苯噻嗪

盐酸甲苯噻嗪用途

Xylazine盐酸盐是α2肾上腺素受体激动剂。
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盐酸甲苯噻嗪名称

[ CAS 号 ]:
23076-35-9

[ 中文名 ]:
盐酸甲苯噻嗪

[ 英文名 ]:
Xylazine hydrochloride

[中文别名 ]:

[英文别名 ]:

盐酸甲苯噻嗪生物活性

[ 描述 ]:

Xylazine盐酸盐是α2肾上腺素受体激动剂。

[ 相关类别 ]:

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 肾上腺素能受体
研究领域 >> 神经疾病

[参考文献]

[1]. Reyes, J.C., et al., The emerging of xylazine as a new drug of abuse and its health consequences among drug users in Puerto Rico. J Urban Health, 2012. 89(3): p. 519-26.

[2]. Hsu, W.H., Xylazine-induced depression and its antagonism by alpha adrenergic blocking agents. J Pharmacol Exp Ther, 1981. 218(1): p. 188-92.


[相关活性小分子]

盐酸异丙肾上腺素 | ICI 118,551盐酸盐 | 盐酸去氧肾上腺素 | 盐酸育亨宾 | 肾上腺素 | 盐酸伊伐布雷定 | 盐酸哌唑嗪 | 盐酸克仑特罗 | 甲磺酸酚妥拉明 | 盐酸胍法辛 | 匹莫齐特 | 盐酸索他洛尔 | 卡维地洛 | 阿替洛尔 | 琥珀酸美托洛尔

盐酸甲苯噻嗪物理化学性质

[ 密度 ]:
1.15g/cm3

[ 沸点 ]:
334.2ºC at 760mmHg

[ 熔点 ]:
150-164?C (dec.)

[ 分子式 ]:
C12H17ClN2S

[ 分子量 ]:
256.795

[ 闪点 ]:
155.9ºC

[ 精确质量 ]:
256.080109

[ PSA ]:
49.69000

[ LogP ]:
3.51880

[ 外观性状 ]:
白色至浅黄色粉末

[ 蒸汽压 ]:
0.00013mmHg at 25°C

[ 储存条件 ]:
−20°C

盐酸甲苯噻嗪MSDS

详细MSDS(安全技术说明书)

盐酸甲苯噻嗪毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :
XJ0776350
CHEMICAL NAME :
4H-1,3-Thiazine, 5,6-dihydro-2-(2,6-xylidino)-, monohydrochloride
CAS REGISTRY NUMBER :
23076-35-9
LAST UPDATED :
199609
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C12-H16-N2-S.Cl-H
MOLECULAR WEIGHT :
256.82
WISWESSER LINE NOTATION :
T6N CS AUTJ BMR B1 F1 &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intramuscular
SPECIES OBSERVED :
Human - man
DOSE/DURATION :
14 mg/kg
TOXIC EFFECTS :
Behavioral - coma Cardiac - EKG changes not diagnostic of specified effects Lungs, Thorax, or Respiration - other changes
REFERENCE :
CTOXAO Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For publisher information, see JTCTDW. Volume(issue)/page/year: 15,281,1979
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intramuscular
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
109 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ZYYZEW Zhongguo Yaolixue Yu Dulixue Zazhi. (Chinese Pharmacological Society, 27 Tai-Ping Road, Beijing 100850, China) V.1- 1986- Volume(issue)/page/year: 9,96,1995
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intramuscular
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
47 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CTOXAO Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For publisher information, see JTCTDW. Volume(issue)/page/year: 15,281,1979
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intramuscular
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
10 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
VHTODE Veterinary and Human Toxicology. (American College of Veterinary and Comparative Toxicology, Publication Office, Comparative Toxicology, Manhattan, KS 66506) V.19- 1977- Volume(issue)/page/year: 24,410,1982
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盐酸甲苯噻嗪安全信息

[ 符号 ]:

GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301-H315-H319-H335

[ 警示性声明 ]:
Missing Phrase - N15.00950417-P305 + P351 + P338

[ 个人防护装备 ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
T: Toxic;

[ 风险声明 (欧洲) ]:
R25;R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36/37/39-S45

[ 危险品运输编码 ]:
2811

[ WGK德国 ]:
-

[ RTECS号 ]:
XJ0776350

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1(b)

[ 海关编码 ]:
2934999090

盐酸甲苯噻嗪制备
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盐酸甲苯噻嗪海关

[ 海关编码 ]: 2934999090

[ 中文概述 ]:
2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

盐酸甲苯噻嗪文献

Poly(ADP-Ribose) Polymerase Inhibition Improves Corneal Epithelial Innervation and Wound Healing in Diabetic Rats.

Invest. Ophthalmol. Vis. Sci. 56(3) , 1948-55, (2015)

We evaluated the effect of poly(ADP-ribose) polymerase (PARP) inhibition by using 1,5-isoquinolinediol (ISO) on corneal epithelial innervation in diabetic rats.ISO (3 mg/kg, intraperitoneal) or vehicl...

Disentangling the Complexity of HGF Signaling by Combining Qualitative and Quantitative Modeling.

PLoS Comput. Biol. 11 , e1004192, (2015)

Signaling pathways are characterized by crosstalk, feedback and feedforward mechanisms giving rise to highly complex and cell-context specific signaling networks. Dissecting the underlying relations i...

Chemical genetics reveals a complex functional ground state of neural stem cells.

Nat. Chem. Biol. 3(5) , 268-273, (2007)

The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain canc...


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