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8-溴腺苷5'-单磷酸

8-溴腺苷5'-单磷酸用途

8-溴-AMP(8-溴-5'-一磷酸腺苷)是一种膜渗透性cAMP类似物。8-溴-AMP可通过增加ATP、ADP和总腺嘌呤核苷酸的水平,提高心脏从缺血和再灌注中恢复的能力[1][2]。

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8-溴腺苷5'-单磷酸名称

[ CAS 号 ]:
23567-96-6

[ 中文名 ]:
8-溴腺苷5'-单磷酸

[ 英文名 ]:
8-Bromo-AMP

[英文别名 ]:

8-Bromoadenosine 5'-phosphate
8-Bromoadenosine 5'-monophosphate
Adenosine,8-bromo-,5'-(dihydrogen phosphate) (8CI)
8-Bromo-5'-AMP
5'-Adenylic acid,8-bromo
8-Bromoadenosine 5'-(dihydrogen phosphate)
8-Bromo-AMP
8-Bromoadenylic acid

8-溴腺苷5'-单磷酸生物活性

[ 描述 ]:

8-溴-AMP(8-溴-5'-一磷酸腺苷)是一种膜渗透性cAMP类似物。8-溴-AMP可通过增加ATP、ADP和总腺嘌呤核苷酸的水平,提高心脏从缺血和再灌注中恢复的能力[1][2]。

[ 相关类别 ]:

研究领域 >> 心血管疾病

信号通路 >> 其他 >> 其他

[参考文献]

[1]. Jiang J, et, al. Evidences for involvement of endogenous cAMP in Arabidopsis defense responses to Verticillium toxins. Cell Res. 2005 Aug;15(8):585-92.

[2]. Nakai T, et, al. Effects of adenine nucleotide analogues on myocardial dysfunction during reperfusion after ischemia in dogs. J Cardiovasc Pharmacol. 1996 Aug;28(2):264-70.

8-溴腺苷5'-单磷酸物理化学性质

[ 分子式 ]:
C₁₀H₁₁BrN₅O₇P

[ 分子量 ]:
424.10100

[ 精确质量 ]:
422.95800

[ PSA ]:
201.54000

[ LogP ]:
0.35710

[ 储存条件 ]:
-20°C，密封，干燥

8-溴腺苷5'-单磷酸MSDS

详细MSDS(安全技术说明书)

8-溴腺苷5'-单磷酸安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

8-溴腺苷5'-单磷酸文献

Recipient pretransplant inosine monophosphate dehydrogenase activity in nonmyeloablative hematopoietic cell transplantation.

Biol. Blood Marrow Transplant. 20(10) , 1544-52, (2014)

Mycophenolic acid, the active metabolite of mycophenolate mofetil (MMF), inhibits inosine monophosphate dehydrogenase (IMPDH) activity. IMPDH is the rate-limiting enzyme involved in de novo synthesis ...

Regulation of P450 oxidoreductase by gonadotropins in rat ovary and its effect on estrogen production.

Reprod. Biol. Endocrinol. 6 , 62, (2009)

P450 oxidoreductase (POR) catalyzes electron transfer to microsomal P450 enzymes. Its deficiency causes Antley-Bixler syndrome (ABS), and about half the patients with ABS have ambiguous genitalia and/...

Tonically Active cAMP-Dependent Signaling in the Ventrolateral Medulla Regulates Sympathetic and Cardiac Vagal Outflows.

J. Pharmacol. Exp. Ther. 356 , 424-33, (2016)

The ventrolateral medulla contains presympathetic and vagal preganglionic neurons that control vasomotor and cardiac vagal tone, respectively. G protein-coupled receptors influence the activity of the...

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