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1,2,7,8-二环氧辛烷

1,2,7,8-二环氧辛烷用途

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1,2,7,8-二环氧辛烷名称

[ CAS 号 ]:
2426-07-5

[ 中文名 ]:
1,2,7,8-二环氧辛烷

[ 英文名 ]:
1,2,7,8-Diepoxyoctane

[中文别名 ]:

[英文别名 ]:

octane-1,2,7,8-diepoxide
1,7-Octadiene Diepoxide
Octane,1,2:7,8-diepoxy
Oxirane, 2,2'-(1,4-butanediyl)bis-
2,2'-Butane-1,4-diyldioxirane
EINECS 219-375-9
MFCD00005155
2,2'-(1,4-Butanediyl)dioxirane
UNII:4IJ1M5W7LL
1,2-Epoxy-7,8-epoxyoctane

1,2,7,8-二环氧辛烷物理化学性质

[ 密度 ]:
0.997

[ 沸点 ]:
240.0±0.0 °C at 760 mmHg

[ 分子式 ]:
C₈H₁₄O₂

[ 分子量 ]:
142.196

[ 闪点 ]:
98 ºC

[ 精确质量 ]:
142.099380

[ PSA ]:
25.06000

[ LogP ]:
0.86

[ 外观性状 ]:
液体;Colorless to Light yellow clear liquid

[ 蒸汽压 ]:
0.1±0.4 mmHg at 25°C

[ 折射率 ]:
1.445

[ 储存条件 ]:
室温

1,2,7,8-二环氧辛烷MSDS

1,2,7,8-二环氧辛烷毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: RG9450000

CAS REGISTRY NUMBER :: 2426-07-5

BEILSTEIN REFERENCE NO. :: 0104873

LAST UPDATED :: 199710

DATA ITEMS CITED :: 15

MOLECULAR FORMULA :: C8-H14-O2

MOLECULAR WEIGHT :: 142.22

WISWESSER LINE NOTATION :: T3OTJ B4- BT3OTJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Open irritation test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1070 uL/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 320 uL/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 6600 mg/kg/55W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Skin and Appendages - tumors Tumorigenic - tumors at site of application

TYPE OF TEST :: Specific locus test

MUTATION DATA

TYPE OF TEST :: Mutation in mammalian somatic cells

TEST SYSTEM :: Rodent - hamster Lung

DOSE/DURATION :: 12500 nmol/L

REFERENCE :: JEPTDQ Journal of Environmental Pathology and Toxicology. (Park Forest South, IL) V.1-5(3), 1977-81(?). For publisher information, see JEPOEC. Volume(issue)/page/year: 2(2),587,1979

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1,2,7,8-二环氧辛烷安全信息

[ 符号 ]:

GHS06, GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H302-H311-H341-H350

[ 警示性声明 ]:
P201-P280-P308 + P313

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
T:Toxic;

[ 风险声明 (欧洲) ]:
R22;R24;R40

[ 安全声明 (欧洲) ]:
S36/37/39-S45

[ 危险品运输编码 ]:
UN 2810 6.1/PG 3

[ WGK德国 ]:
3

[ RTECS号 ]:
RG9450000

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1

[ 海关编码 ]:
2910900090

1,2,7,8-二环氧辛烷合成路线

1,2,7,8-二环氧辛烷海关

[ 海关编码 ]: 2910900090

[ 中文概述 ]:
2910900090. 三节环环氧化物，环氧醇（酚，醚），包括其卤化，磺化，硝化或亚硝化的衍生物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:5.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2910900090. epoxides, epoxyalcohols, epoxyphenols and epoxyethers, with a three-membered ring, and their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0%

1,2,7,8-二环氧辛烷文献

Further phenotypic characterization of pso mutants of Saccharomyces cerevisiae with respect to DNA repair and response to oxidative stress.

Genet. Mol. Res. 1(1) , 79-89, (2002)

The sensitivity responses of seven pso mutants of Saccharomyces cerevisiae towards the mutagens N-nitrosodiethylamine (NDEA), 1,2:7,8-diepoxyoctane (DEO), and 8-hydroxyquinoline (8HQ) further substant...

Discrimination between genotoxicity and cytotoxicity for the induction of DNA double-strand breaks in cells treated with aldehydes and diepoxides.

Mutat. Res. 441(1) , 85-93, (1999)

The time-dependent dose-response relationships for the induction of DNA double-strand breaks (DSB) assessed by pulsed-field gel electrophoresis (PFGE) and for viability (evaluated by the MTT cytotoxic...

1,2,5,6-Diepoxyhexane and 1,2,7,8-diepoxyoctane cross-link duplex DNA at 5'-GNC sequences.

Chem. Res. Toxicol. 9(6) , 994-1000, (1996)

The carcinogenicity of epoxide compounds has been attributed to covalent binding to DNA. Whereas monoepoxides form only monoadducts, diepoxides can form both monoadducts and interstrand cross-links. T...

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