5-甲氧基-1-茚酮-3-乙酸

5-甲氧基-1-茚酮-3-乙酸名称

[ CAS 号 ]:
24467-92-3

[ 中文名 ]:
5-甲氧基-1-茚酮-3-乙酸

[ 英文名 ]:
2-(6-METHOXY-3-OXO-2,3-DIHYDRO-1H-INDEN-1-YL)ACETIC ACID

[中文别名 ]:

[英文别名 ]:

(6-Methoxy-3-oxo-indan-1-yl)-essigsaeure
6-Methoxy-3-oxo-1-indanacetic acid
(6-methoxy-3-oxo-indan-1-yl)-acetic acid
MFCD00003787
5-Methoxy-1-indanone-3-acetic acid

5-甲氧基-1-茚酮-3-乙酸物理化学性质

[ 密度 ]:
1.286g/cm3

[ 沸点 ]:
428.7ºC at 760mmHg

[ 熔点 ]:
139-144ºC(lit.)

[ 分子式 ]:
C₁₂H₁₂O₄

[ 分子量 ]:
220.22100

[ 闪点 ]:
170.6ºC

[ 精确质量 ]:
220.07400

[ PSA ]:
63.60000

[ LogP ]:
1.83990

[ 蒸汽压 ]:
4.11E-08mmHg at 25°C

[ 折射率 ]:
1.569

5-甲氧基-1-茚酮-3-乙酸MSDS

5-甲氧基-1-茚酮-3-乙酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NK8225760

CHEMICAL NAME :: 1H-Indene-1-acetic acid, 2,3-dihydro-6-methoxy-3-oxo-

CAS REGISTRY NUMBER :: 24467-92-3

BEILSTEIN REFERENCE NO. :: 2118149

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C12-H12-O4

MOLECULAR WEIGHT :: 220.24

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: IJPPAZ Indian Journal of Physiology and Pharmacology. (All India Institute of Medical Sciences, Dept. of Physiology, Ansari Nagar, New Delhi 110 029, India) V.1- 1957- Volume(issue)/page/year: 24,310,1980

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5-甲氧基-1-茚酮-3-乙酸安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
NK8225760

[ 海关编码 ]:
2918990090

5-甲氧基-1-茚酮-3-乙酸合成路线

5-甲氧基-1-茚酮-3-乙酸上下游产品

5-甲氧基-1-茚酮-3-乙酸上游产品

5-甲氧基-1-茚酮-3-乙酸下游产品

5-甲氧基-1-茚酮-3-乙酸海关

[ 海关编码 ]: 2918990090

[ 中文概述 ]:
2918990090. 其他含其他附加含氧基羧酸（包括酸酐、酰卤化物、过氧化物和过氧酸及该税号的衍生物）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

5-甲氧基-1-茚酮-3-乙酸文献

Selective inhibition of the chymotrypsin-like activity of the 20S proteasome by 5-methoxy-1-indanone dipeptide benzamides.

Bioorg. Med. Chem. Lett. 8(3) , 209-14, (1998)

Potent inhibitors of the 20S proteasome that contain a novel indanone head group coupled to di and tripeptides are described. These compounds are the first proteasome inhibitors have demonstrated high...

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