1-乙酰基咪唑
1-乙酰基咪唑用途
用作医药中间体
【用途二】
作乙酰化试剂,供生化研究用。
1-乙酰基咪唑名称
[ CAS 号 ]:
2466-76-4
[ 中文名 ]:
1-乙酰基咪唑
[ 英文名 ]:
1-acetylimidazole
[中文别名 ]:
[英文别名 ]:
- MFCD00005287
- N-Acetylimidazole
- 1-Acetyl-1H-imidazole
- Ethanone, 1-(1H-imidazol-1-yl)-
- EINECS 219-577-7
- 1-(1H-Imidazol-1-yl)ethanone
- Acetylimidazole
- 1-acetylimidazole
- IMIDAZOLE,1-ACETYL
- 1H-Imidazole,1-acetyl
1-乙酰基咪唑物理化学性质
[ 密度 ]:
1.1±0.1 g/cm3
[ 沸点 ]:
222.0±23.0 °C at 760 mmHg
[ 熔点 ]:
99-105 °C(lit.)
[ 分子式 ]:
C5H6N2O
[ 分子量 ]:
110.114
[ 闪点 ]:
88.0±22.6 °C
[ 精确质量 ]:
110.048012
[ PSA ]:
34.89000
[ LogP ]:
-0.34
[ 外观性状 ]:
白色至淡黄色晶体
[ 蒸汽压 ]:
0.1±0.4 mmHg at 25°C
[ 折射率 ]:
1.552
[ 储存条件 ]:
库房通风低温干燥
1-乙酰基咪唑MSDS
1-乙酰基咪唑毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- NI3400000
- CHEMICAL NAME :
- Imidazole, 1-acetyl-
- CAS REGISTRY NUMBER :
- 2466-76-4
- BEILSTEIN REFERENCE NO. :
- 0108425
- LAST UPDATED :
- 199701
- DATA ITEMS CITED :
- 3
- MOLECULAR FORMULA :
- C5-H6-N2-O
- MOLECULAR WEIGHT :
- 110.13
- WISWESSER LINE NOTATION :
- T5N CNJ AV1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 250 mg/kg
- TOXIC EFFECTS :
- Immunological Including Allergic - decreased immune response
- REFERENCE :
- StoGD# Personal Communication from G.D. Stoner, Dept. of Community Medicine, School of Medicine, Univ. of California, La Jolla, CA 92037, May 25, 1975 Volume(issue)/page/year: 27MAY1975 ** TUMORIGENIC DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 50 mg/kg/I
- TOXIC EFFECTS :
- Tumorigenic - neoplastic by RTECS criteria Lungs, Thorax, or Respiration - tumors
- REFERENCE :
- JNCIAM Journal of the National Cancer Institute. (Washington, DC) V.1-60, 1940-78. For publisher information, see JJIND8. Volume(issue)/page/year: 54,495,1975
1-乙酰基咪唑安全信息
[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
[ 危害码 (欧洲) ]:
Xn
[ 风险声明 (欧洲) ]:
R36/37/38
[ 安全声明 (欧洲) ]:
S24/25
[ 危险品运输编码 ]:
NONH for all modes of transport
[ WGK德国 ]:
3
[ RTECS号 ]:
NI3400000
[ 海关编码 ]:
2933290090
1-乙酰基咪唑上下游产品
1-乙酰基咪唑上游产品
1-乙酰基咪唑下游产品
1-乙酰基咪唑制备
1.咪唑与乙酸异丙烯酯反应在50毫升圆烧瓶中,加入0.2g(0.03mol)咪唑,20ml乙酸异丙烯酯和几滴浓硫酸。将混合物在60℃保温1h。蒸馏除去少量的乙酸异丙烯酯和丙酮。剩余物用水碳酸钠处理。倾出液体。在空气浴中蒸发至干。得粗品3.1g,产率94%,熔点93-96℃。现经乙酸异丙烯酯重结晶,熔点达到101.5102.5℃。
1-乙酰基咪唑海关
[ 海关编码 ]: 2933290090
[ 中文概述 ]:
2933290090. 其他结构含非稠合咪唑环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6-己内酰胺请注明外观, 签约日期
[ Summary ]:
2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
1-乙酰基咪唑文献
Nucleic Acids Res. 30(6) , 1325-32, (2002)
The caspase-activated DNase (CAD) is involved in DNA degradation during apoptosis. Chemical modification of murine CAD with the lysine-specific reagent 2,4,6-trinitrobenzenesulphonic acid and the tyro...
Changes in the level and activation state of the plasma membrane H(+)-ATPase during aging of red beet slices.Plant Physiol. 114(3) , 857-62, (1997)
The effect of aging on the plasma membrane (PM) H(+)-ATPase of red beet (Beta vulgaris L.) parenchyma discs was analyzed in PM purified by aqueous two-phase partitioning. Aging increased both the acti...
Chemical modification of active site residues in gamma-glutamyl transpeptidase. Aspartate 422 and cysteine 453.J. Biol. Chem. 270(21) , 12476-80, (1995)
gamma-Glutamyl transpeptidase, an enzyme of central significance in glutathione metabolism, is inactivated by iodoacetamide, which esterifies an active site carboxyl group identified here as that of A...
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