< 生产厂家 价格 >

利血那明

利血那明用途

胺是吲哚生物碱利血平的衍生物。胺具有镇静作用。胺可用于高血压研究[1][2]。
点击显示

利血那明名称

[ CAS 号 ]:
24815-24-5

[ 中文名 ]:
利血那明

[ 英文名 ]:
Anaprel

[中文别名 ]:

[英文别名 ]:

利血那明生物活性

[ 描述 ]:

胺是吲哚生物碱利血平的衍生物。胺具有镇静作用。胺可用于高血压研究[1][2]。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他
研究领域 >> 代谢疾病

[参考文献]

[1]. AbdelHafez EM, et al. Computational and synthetic studies towards improving rescinnamine as an inducer of MSH2-dependent apoptosis in cancer treatment. Mol Cancer Biol. 2013;1(1):44.

[2]. CRONHEIM G, et al. Pharmacological studies with rescinnamine, a new alkaloid isolated from Rauwolfia serpentina. Proc Soc Exp Biol Med. 1954 May;86(1):120-4.

利血那明物理化学性质

[ 密度 ]:
1.31g/cm3

[ 沸点 ]:
756.8ºC at 760 mmHg

[ 熔点 ]:
238ºC

[ 分子式 ]:
C35H42N2O9

[ 分子量 ]:
634.71600

[ 闪点 ]:
411.5ºC

[ 精确质量 ]:
634.28900

[ PSA ]:
117.78000

[ LogP ]:
4.50860

[ 外观性状 ]:
白色至奶油色粉末

[ 蒸汽压 ]:
8.5E-23mmHg at 25°C

[ 折射率 ]:
1.621

[ 储存条件 ]:
2-8°C， 密封， 干燥， 避光

利血那明MSDS

详细MSDS(安全技术说明书)

利血那明毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :
ZG0700000
CHEMICAL NAME :
3-beta,20-alpha-Yohimban-16-beta-carboxylic acid, 18-beta-hydroxy-11,17-alpha-dimethoxy-, methyl ester, 3,4,5-trimethoxycinnamate (ester)
CAS REGISTRY NUMBER :
24815-24-5
BEILSTEIN REFERENCE NO. :
0075328
LAST UPDATED :
199803
DATA ITEMS CITED :
10
MOLECULAR FORMULA :
C35-H42-N2-O9
MOLECULAR WEIGHT :
634.79
WISWESSER LINE NOTATION :
T F6 D5 C666 EM ON&&TTTJ HO1 SOV1U1R CO1 DO1 EO1& TO1 UVO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human
DOSE/DURATION :
4 ug/kg/D
TOXIC EFFECTS :
Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Behavioral - somnolence (general depressed activity) Behavioral - antipsychotic
REFERENCE :
34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969 Volume(issue)/page/year: -,517,1969
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,898,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
250 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,898,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
540 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,898,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1420 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,109,1972
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
65 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FMXXAJ French Medicament Patent Document. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Discontinued. Volume(issue)/page/year: #5226M
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
263 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FMXXAJ French Medicament Patent Document. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Discontinued. Volume(issue)/page/year: #5226M
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
56 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#00965
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
35 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 23,600,1973 ** REPRODUCTIVE DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
32 ug/kg
SEX/DURATION :
male 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - other effects on male
REFERENCE :
NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 80,239,1982
点击显示

利血那明安全信息

[ 危害码 (欧洲) ]:
Xn

[ 风险声明 (欧洲) ]:
25-20/21/22

[ 安全声明 (欧洲) ]:
22-45-36

[ 危险品运输编码 ]:
UN 1544

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1(b)

利血那明合成路线

详细合成路线

利血那明上下游产品

利血那明上游产品

利血那明下游产品

推荐生产厂家/供应商：

公司名：上海吉至生化科技有限公司

区域：上海市奉贤区

价格：
￥4418.0/5mg

联系人：刘佳

产品详情：利血那明

公司名：上海源溪生物科技有限公司

区域：上海市浦东新区

价格：
￥需询单/1g

联系人：赖经理

产品详情：Anaprel

查看所有供应商请点击：

利血那明供应商

相关化合物

【利血那明】化源网提供利血那明CAS号24815-24-5，利血那明MSDS及其说明、性质、英文名、生产厂家、作用/用途、分子量、密度、沸点、熔点、结构式等。CAS号查询利血那明上化源网，专业又轻松。>>电脑版：利血那明

标题：利血那明_MSDS_用途_密度_利血那明CAS号【24815-24-5】_化源网 地址：https://m.chemsrc.com/mip/cas/24815-24-5_673011.html