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(S)-ATPO

(S)-ATPO用途

(S) -ATPO是ATPO的(S)-对映体,是GluR1-4(AMPA偏好)受体的竞争性拮抗剂[1]。

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(S)-ATPO名称

[ CAS 号 ]:
252930-37-3

[ 中文名 ]:
(AlphaS)-Alpha-氨基-5-(叔丁基)-3-(膦酰甲氧基)-4-异恶唑丙酸

[ 英文名 ]:
(S)-ATPO

[英文别名 ]:

HMS3260C06
ATPO

(S)-ATPO生物活性

[ 描述 ]:

(S) -ATPO是ATPO的(S)-对映体,是GluR1-4(AMPA偏好)受体的竞争性拮抗剂[1]。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 神经疾病

[体外研究]

ATPO是GluR1-4(AMPA偏好)受体的竞争性拮抗剂[1]。

[参考文献]

[1]. Hogner A, et al. Competitive antagonism of AMPA receptors by ligands of different classes: crystal structure of ATPO bound to the GluR2 ligand-binding core, in comparison with DNQX. J Med Chem. 2003;46(2):214-221.

(S)-ATPO物理化学性质

[ 沸点 ]:
569.2±60.0 °C

[ 分子式 ]:
C₁₁H₁₉N₂O₇P

[ 分子量 ]:
322.25

[ 精确质量 ]:
322.09300

[ PSA ]:
165.92000

[ LogP ]:
1.14080

[ 外观性状 ]:
白色固体

[ 储存条件 ]:
2-8°C

(S)-ATPOMSDS

详细MSDS(安全技术说明书)

(S)-ATPO安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

(S)-ATPO文献

Synthesis and pharmacology of highly selective carboxy and phosphono isoxazole amino acid AMPA receptor antagonists.

J. Med. Chem. 39 , 1682-1691, (1996)

(RS)-2-Amino-3-(3-hydroxy-5-methyl-4-isoxazolyl)propionic acid (AMPA, 5) and the selective AMPA receptor antagonist (RS)-2-amino-3-[3-(carboxymethoxy)-5-methyl-4-isoxazolyl]propionic acid (AMOA, 7) ha...

Resolution, absolute stereochemistry, and enantiopharmacology of the GluR1-4 and GluR5 antagonist 2-amino-3-[5-tert-butyl-3-(phosphonomethoxy)-4-isoxazolyl]propionic acid.

Chirality 11 , 752-9, (1999)

The phosphono amino acid, (RS)-2-amino-3-[5-tert-butyl-3-(phosphonomethoxy)-4-isoxazolyl+ ++]propio nic acid (ATPO), is a structural hybrid between the NMDA antagonist (RS)-2-amino-7-phosphonoheptanoi...

Antagonist properties of a phosphono isoxazole amino acid at glutamate R1-4 (R,S)-2-amino-3-(3-hydroxy-5-methyl-4-isoxazolyl)propionic acid receptor subtypes.

Mol. Pharmacol. 53 , 590-6, (1998)

The activity of the (R, S)-2-amino-3-(3-hydroxy-5-methyl-4-isoxazolyl)propionic acid (AMPA) receptor antagonist, (R,S) -2-amino-3-[5-tert-butyl-3-(phosphonomethoxy)-4-isoxazolyl] propionic acid (ATPO)...

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