Glycine,N,N-bis(2-chloroethyl)-, hydrochloride (6CI,7CI,8CI,9CI)

名称

[ CAS 号 ]:
2619-97-8

[ 英文名 ]:
Glycine,N,N-bis(2-chloroethyl)-, hydrochloride (6CI,7CI,8CI,9CI)

[英文别名 ]:

N,N-Bis(2-chloraethyl)formamid
N,N-Bis-(2-chlor-aethyl)-glycin,Hydrochlorid
N,N-bis-(2-chloro-ethyl)formamide
Ameisensaeure-[bis-(2-chlor-aethyl)-amid]
2-<Bis-(2-chlorethyl)-amino>-essigsaeure
N,N-bis-(2-chloro-ethyl)-glycine,hydrochloride
FORMAMIDE,N,N-BIS(2-CHLOROETHYL)

物理化学性质

[ 密度 ]:
1.314g/cm3

[ 沸点 ]:
236ºC at 760 mmHg

[ 分子式 ]:
C₆H₁₂Cl₃NO₂

[ 分子量 ]:
236.52400

[ 闪点 ]:
96.5ºC

[ 精确质量 ]:
234.99300

[ PSA ]:
40.54000

[ LogP ]:
1.65260

[ 蒸汽压 ]:
0.0167mmHg at 25°C

[ 折射率 ]:
1.5

毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MB8480000

CHEMICAL NAME :: Glycine, N,N-bis(2-chloroethyl)-, hydrochloride

CAS REGISTRY NUMBER :: 2619-97-8

LAST UPDATED :: 199203

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C6-H11-Cl2-N-O2.Cl-H

MOLECULAR WEIGHT :: 236.54

WISWESSER LINE NOTATION :: QV1N2G2G &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intracerebral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 113 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPPMAB Journal of Pharmacy and Pharmacology. (Pharmaceutical Soc. of Great Britain, 1 Lambeth High St., London SEI 7JN, UK) V.1- 1949- Volume(issue)/page/year: 18,760,1966

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 15 mg/kg

TOXIC EFFECTS :: Tumorigenic - active as anti-cancer agent

REFERENCE :: PHBUA9 Pharmaceutical Bulletin. (Tokyo, Japan) V.1-5, 1953-57. For publisher information, see CPBTAL. Volume(issue)/page/year: 2,275,1954

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 1 mg/kg

TOXIC EFFECTS :: Gastrointestinal - other changes Blood - leukopenia Blood - other changes

REFERENCE :: CCSUBJ Cancer Chemotherapy Reports, Part 2. (Washington, DC) V.1-5, 1964-75. For publisher information, see CTRRDO. Volume(issue)/page/year: 2,201,1965

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Primate - monkey

DOSE/DURATION :: 1 mg/kg

TOXIC EFFECTS :: Blood - leukopenia Blood - other changes

REFERENCE :: CCSUBJ Cancer Chemotherapy Reports, Part 2. (Washington, DC) V.1-5, 1964-75. For publisher information, see CTRRDO. Volume(issue)/page/year: 2,201,1965

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